Lipases in asymmetric transformations: Recent advances in classical kinetic resolution and lipase–metal combinations for dynamic processes
Sign Up to like & getrecommendations! Published in 2017 at "Coordination Chemistry Reviews"
DOI: 10.1016/j.ccr.2017.08.008
Abstract: Abstract The importance of chiral organic intermediates in various industrial sectors cannot be underestimated. Lipases and their use in combination with metal catalysts is a promising and facile approach to obtain enantiomerically pure chiral intermediates… read more here.
Keywords: asymmetric transformations; kinetic resolution; lipases asymmetric; metal ... See more keywords
Advances in Stereoconvergent Catalysis from 2005 to 2015: Transition-Metal-Mediated Stereoablative Reactions, Dynamic Kinetic Resolutions, and Dynamic Kinetic Asymmetric Transformations.
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DOI: 10.1021/acs.chemrev.6b00731
Abstract: Stereoconvergent catalysis is an important subset of asymmetric synthesis that encompasses stereoablative transformations, dynamic kinetic resolutions, and dynamic kinetic asymmetric transformations. Initially, only enzymes were known to catalyze dynamic kinetic processes, but recently various synthetic… read more here.
Keywords: asymmetric transformations; resolutions dynamic; stereoconvergent catalysis; kinetic asymmetric ... See more keywords
Catalytic asymmetric transformations of racemic α-borylmethyl-(E)-crotylboronate via kinetic resolution or enantioconvergent reaction pathways
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DOI: 10.1039/d1sc04047b
Abstract: We report herein catalytic asymmetric transformations of racemic α-borylmethyl-(E)-crotylboronate. The Brønsted acid-catalyzed kinetic resolution–allylboration reaction sequence of the racemic reagent gave (Z)-δ-hydroxymethyl-anti-homoallylic alcohols with high Z-selectivities and enantioselectivities upon oxidative workup. In parallel, enantioconvergent pathways… read more here.
Keywords: asymmetric transformations; kinetic resolution; transformations racemic; racemic borylmethyl ... See more keywords
Organocatalytic asymmetric transformations of 3-substituted 3-hydroxyisoindolinones
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DOI: 10.1055/s-0036-1588759
Abstract: This Account provides an overview of our group’s research in the field of asymmetric organocatalytic transformations generating chiral isoindolinone cores. We describe the synthesis of 3-substituted 3-hydroxyisoindolinones as starting materials for these transformations, comprising a… read more here.
Keywords: substituted hydroxyisoindolinones; asymmetric transformations; organocatalytic asymmetric; transformations substituted ... See more keywords