Total Synthesis of the Acetyl CoA Carboxylase Inhibitor Soraphen A: Asymmetric Tsuji Reduction Enables Successive Olefin Metathesis.
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DOI: 10.1021/jacs.1c12063
Abstract: The total synthesis of soraphen A, a myxobacterial metabolite and inhibitor of acetyl CoA carboxylase, was completed in 11 steps (longest linear sequence), less than half the steps previously required. Seven metal-catalyzed processes were deployed… read more here.
Keywords: coa carboxylase; acetyl coa; tsuji reduction; total synthesis ... See more keywords
Interrupting Associative π-σ-π Isomerization Enables Z-Retentive Asymmetric Tsuji-Trost Reaction.
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DOI: 10.1021/jacs.4c15635
Abstract: The asymmetric Tsuji-Trost reaction has been extensively studied due to its importance in establishing stereogenic centers, often adjacent to an E-olefin moiety in organic molecules. The generally preferential formation of chiral E-olefin products is believed… read more here.
Keywords: associative isomerization; tsuji trost; asymmetric tsuji;