Asymmetric Umpolung (3+2) Cycloadditions of Iminoesters with α,β-Unsaturated-2-acyl Imidazoles for the Synthesis of Substituted Pyrrolidines.
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DOI: 10.1021/acs.orglett.2c01438
Abstract: An enantioselective (3+2) cycloaddition reaction of iminoesters occurring with opposite regioselectivity is reported. This reaction provides chiral polysubstituted pyrrolidines with high enantioselectivities (up to 97%), diastereoselectivities (>20:1), and yields (up to 99%). Interestingly, changing the… read more here.
Keywords: iminoesters unsaturated; asymmetric umpolung; cycloadditions iminoesters; acyl imidazoles ... See more keywords
Iridium-Catalyzed Asymmetric Umpolung Allylation of N-Fluorenyl Imines to Prepare 1,4-Disubstituted Homoallylic Amines
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DOI: 10.1055/s-0036-1588514
Abstract: The discovery and development of an Ir-catalyzed asymmetric umpolung allylation of imines is discussed here. This method produces 1,4-disubstituted homoallylic amines, a class of compounds that are difficult to access by conventional methods. This reaction… read more here.
Keywords: catalyzed asymmetric; homoallylic amines; umpolung allylation; asymmetric umpolung ... See more keywords