Changes in the function of angiotensin II type 1 receptor due to cholesterol depletion from cell membrane.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.05.015
Abstract: Blockers of G-protein coupled receptors (GPCRs), angiotensin II (Ang II) type 1 (AT1) receptor and β1-adrenergic (Ad) receptor, have been shown to improve the prognosis of cardiovascular disease. Cholesterol molecules in the cell membrane are… read more here.
Keywords: cholesterol depletion; at1 receptor; receptor; cell ... See more keywords
Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury
Sign Up to like & getrecommendations! Published in 2021 at "Cell Research"
DOI: 10.1038/s41422-020-00464-8
Abstract: Compelling evidence has revealed that biased activation of G protein-coupled receptor (GPCR) signaling, including angiotensin II (AngII) receptor type 1 (AT1) signaling, plays pivotal roles in vascular homeostasis and injury, but whether a clinically relevant… read more here.
Keywords: matrix protein; cartilage oligomeric; at1 receptor; at1 ... See more keywords
New insight into increased angiotensin II type 1 receptor expression in Snx1−/− mice
Sign Up to like & getrecommendations! Published in 2021 at "Hypertension Research"
DOI: 10.1038/s41440-021-00669-3
Abstract: The renin–angiotensin system (RAS) consists of angiotensinogen, renin, angiotensin-converting enzyme, angiotensin II (Ang II) and the Ang II type 1 (AT1) and type 2 (AT2) receptors [1]. RAS activities regulate blood pressure (BP), blood volume,… read more here.
Keywords: receptor; at1 receptor; snx1 mice; expression ... See more keywords
EFFECTS OF A NOVEL INTERACTING MOLECULE WITH AT1 RECEPTOR, ATRAP, ON ANG II-INDUCED PROLIFERATIVE ACTIVITY AND OXIDATIVE STRESS IN VASCULAR SMOOTH MUSCLE CELLS
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000539193.23203.fb
Abstract: Objective: Superoxide anions are recognized as mediators of intracellular signaling cascades and are known to participate in cardiovascular diseases such as arteriosclerosis and hypertension. Previous studies reported that the production of superoxide is modulated by… read more here.
Keywords: muscle cells; at1 receptor; atrap; smooth muscle ... See more keywords
A11971 Angiotensin II AT2 Receptor Decreases AT1 Receptor Expression and Function via NO/cGMP/Sp1 in Renal Proximal Tubule Cells from Wistar-Kyoto Rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548256.82096.b3
Abstract: Objectives: In the kidney, activation of the AT1 receptor increases renal sodium reabsorption, whereas the AT2 receptor produces the opposite effect. We hypothesized that the AT2 receptor regulates AT1 receptor expression and function in the… read more here.
Keywords: receptor; at2 receptor; receptor expression; at1 receptor ... See more keywords
Angiotensin II prompts heart cell apoptosis via AT1 receptor-augmented phosphatase and tensin homolog and miR-320-3p functions to enhance suppression of the IGF1R-PI3K-AKT survival pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/hjh.0000000000003285
Abstract: Background: Hypertension is a severe public health risk factor worldwide. Elevated angiotensin II (Ang II) produced by the renin–angiotensin–aldosterone system can lead to hypertension and its complications. Method: In this study, we addressed the cardiac-injury… read more here.
Keywords: pi3k; pi3k akt; phosphatase tensin; igf1r pi3k ... See more keywords
The non‐biphenyl‐tetrazole angiotensin AT1 receptor antagonist eprosartan is a unique and robust inverse agonist of the active state of the AT1 receptor
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14213
Abstract: Conditions such as hypertension and renal allograft rejection are accompanied by chronic, agonist‐independent, signalling by angiotensin II AT1 receptors. The current treatment paradigm for these diseases entails the preferred use of inverse agonist AT1 receptor… read more here.
Keywords: at1 receptor; at1; inverse agonist; active state ... See more keywords
Autoantibodies against AT1 Receptor Contribute to Vascular Aging and Endothelial Cell Senescence
Sign Up to like & getrecommendations! Published in 2019 at "Aging and Disease"
DOI: 10.14336/ad.2018.0919
Abstract: Vascular aging predisposes the elderly to the progression of many aging-related vascular disorders and leads to deterioration of cardiovascular diseases (CVD). However, the underlying mechanisms have not been clearly elucidated. Agonistic autoantibodies against angiotensin II… read more here.
Keywords: vascular aging; at1 receptor; senescence; contribute ... See more keywords
Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor
Sign Up to like & getrecommendations! Published in 2017 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s144807
Abstract: Angiotensin II (Ang II) is known to be involved in the progression of ventricular dysfunction and heart failure by eliciting cardiac fibrosis. The purpose of this study was to demonstrate whether treatment with an antioxidant… read more here.
Keywords: receptor; at1 receptor; cardiac fibrosis; edaravone ... See more keywords
AT1 receptor as a potential target in amphetamine induced-neuroinflammation.
Sign Up to like & getrecommendations! Published in 2022 at "Protein and peptide letters"
DOI: 10.2174/0929866529666220330154218
Abstract: read more here.
Keywords: at1 receptor; induced neuroinflammation; target amphetamine; amphetamine induced ... See more keywords
Effect of the renin-angiotensin system on the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic mice: Role of angiotensin-II type 2 receptor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1040040
Abstract: Prior investigation shows an increase in the activity of both hypothalamus-pituitary-adrenal (HPA) axis and the renin-angiotensin system (RAS) in diabetic patients. Moreover, activation of angiotensin-II type 1 receptor (AT1) has been associated with adrenal steroidogenesis.… read more here.
Keywords: angiotensin; diabetic mice; mice; receptor ... See more keywords