A validated chiral LC method for the enantiomeric separation of AT13148 on polysaccharide-based chiral stationary phase
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-017-1270-2
Abstract: AbstractA sensitive and accurate LC method for the determination of AT13148 enantiomeric purity has been developed and validated. Baseline separation with a resolution higher than 1.8 was accomplished within 15 min using a Chiralpak AD-H column… read more here.
Keywords: phase; method; chiral method; at13148 ... See more keywords
Study on the mechanism of multi-AGC kinase AT13148 on Notch signaling pathway in glioblastoma
Sign Up to like & getrecommendations! Published in 2021 at "Archives of Medical Science"
DOI: 10.5114/aoms/135083
Abstract: Introduction Glioblastoma is the most malignant astrocytoma, and its therapeutic effect is not ideal. Notch signaling pathway plays an important role in tumor proliferation and invasion. Whether small molecule drug AT13148 can affect glioblastoma by… read more here.
Keywords: glioblastoma; notch signaling; signaling pathway; itgb1 ... See more keywords