Single-molecule force spectroscopy study of interactions between angiotensin II type 1 receptor and different biased ligands in living cells
Sign Up to like & getrecommendations! Published in 2018 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-0956-3
Abstract: AbstractAngiotensin II type 1 receptor (AT1R), a typical G protein-coupled receptor, plays a key role in regulating many cardiovascular functions. Different ligands can bind with AT1R to selectively activate either G protein (Gq) or β-arrestin… read more here.
Keywords: molecule; at1r; force; spectroscopy ... See more keywords
BRET‐based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein‐independent activation and AT1R‐EGFR complexes
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.10.017
Abstract: &NA; The type 1 angiotensin II (AngII) receptor (AT1R) transactivates the epidermal growth factor receptor (EGFR), which leads to pathological remodeling of heart, blood vessels and kidney. End‐point assays are used as surrogates of EGFR… read more here.
Keywords: egfr; at1r; at1r egfr; egfr transactivation ... See more keywords
OR52 AT1R antibody in pediatric heart transplant patients: What are we really detecting
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.058
Abstract: Aim The frequency and impact of AT1R antibodies in pediatric heart transplantation has not been well studied. Our aim was to measure AT1R antibodies (AT1R-Ab) in this patient population and pediatric controls and to assess… read more here.
Keywords: pediatric heart; at1r; transplant; at1r antibody ... See more keywords
P193 Incidence of AT1R- antibody in women with hellp syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.253
Abstract: Aim Antibodies against the angiotensin II type 1 receptor (AT1R-Abs) have been implicated in a number of disease processes, including development of fibrosis in cystic fibrosis and systemic sclerosis, antibody mediated rejection in solid organ… read more here.
Keywords: hellp syndrome; control group; at1r; group ... See more keywords
Histopathological Relevance of Angiotensin II Type 1 Receptor in Renal Transplant Biopsy.
Sign Up to like & getrecommendations! Published in 2018 at "Transplantation proceedings"
DOI: 10.1016/j.transproceed.2018.02.137
Abstract: The occurrence of anti-angiotensin II type 1 receptor (AT1R) antibodies is thought to be a risk factor for transplant injury, but the relationship of AT1R to graft loss in renal transplantation has not been assessed.… read more here.
Keywords: type receptor; biopsy; at1r; renal transplant ... See more keywords
Trans and Cis Conformations of the Antihypertensive Drug Valsartan Respectively Lock the Inactive and Active-like States of Angiotensin II Type 1 Receptor: A Molecular Dynamics Study
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.8b00364
Abstract: Angiotensin II type 1 receptor (AT1R) is the principal regulator of blood pressure in humans. The overactivation of AT1R by the stimulation of angiotensin II would result in high blood pressure. To prevent hypertension, nonpeptide… read more here.
Keywords: type receptor; at1r; trans cis; cis conformations ... See more keywords
Induced antibodies directed to the angiotensin receptor type 1 provoke skin and lung inflammation, dermal fibrosis and act species overarching
Sign Up to like & getrecommendations! Published in 2022 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-222088
Abstract: Objective To determine contributions and functions of autoantibodies (Abs) directed to the angiotensin receptor type 1 (AT1R), which are suggested to be involved in the pathogenesis of AT1R Abs-related diseases such as systemic sclerosis (SSc).… read more here.
Keywords: lung; lung inflammation; skin lung; at1r ... See more keywords
Identification of a locus coeruleus-amygdala angiotensinergic circuit: Implications for anxiogenesis and stress-related cardiovascular disease
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732412
Abstract: Background: The brain renin-angiotensin system (RAS) mediates stress-related cardiovascular diseases. However, the synthetic pathways of angiotensin peptides in the brain, remains unclear. Angiotensin (Ang) II and its receptors have been previously identified in the locus… read more here.
Keywords: amygdala; circuit; physiology; at1r ... See more keywords
Angiotensin II Type 1 Receptor Knockdown Impairs Interleukin‐1&bgr;‐Induced Cytokines in Human Periodontal Fibroblasts
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Periodontology"
DOI: 10.1902/jop.2016.160354
Abstract: BACKGROUND The renin-angiotensin (Ang) system (RAS) has been reported as an important modulator of inflammatory and immune responses. Evidence suggests an alternative Ang 1-7/Mas receptor axis as counter-regulatory to the classic RAS Ang II/Ang II… read more here.
Keywords: human periodontal; hgf hplf; at1r; receptor ... See more keywords
Qing Fei Hua Xian Decoction ameliorates bleomycin-induced pulmonary fibrosis by suppressing oxidative stress through balancing ACE-AngII-AT1R/ACE2-Ang-(1-7)-Mas axis
Sign Up to like & getrecommendations! Published in 2023 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.67042.14700
Abstract: Objective(s): We aimed to investigate the preventative effect of Qing Fei Hua Xian Decoction (QFHXD) against pulmonary fibrosis (PF) and its potential mechanisms. Materials and Methods: Bleomycin (BLM)-induced rats were respectively treated with 413.3, 826.6,… read more here.
Keywords: angiotensin; ang mas; ace; angii ... See more keywords
Functionally Active Antibodies to the Angiotensin II Type 1-Receptor Measured by a Luminometric Bioassay Do Not Correlate With Clinical Manifestations in Systemic Sclerosis: A Comparison With Antibodies to Vascular Receptors and Topoisomerase I Detected by ELISA
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.786039
Abstract: Objectives 1) To detect functionally active antibodies(abs) to the angiotensin II type-1-receptor (AT1R) by a novel luminometric assay. 2) To assess their prevalence in systemic sclerosis (SSc), other collagen disorders, as well as in further… read more here.
Keywords: anti at1r; topo; functionally active; at1r eta1 ... See more keywords