Pulmonary alveolar regeneration in adult COVID-19 patients
Sign Up to like & getrecommendations! Published in 2020 at "Cell Research"
DOI: 10.1038/s41422-020-0369-7
Abstract: Dear Editor, Alveolar regeneration after an acute lung injury has been observed in many mammals. Results in animal models have shown that alveolar type II (AT2) cells function as resident alveolar stem cells that can… read more here.
Keywords: alveolar regeneration; at2 cells; at1 cells; at2 ... See more keywords
Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-51683-1
Abstract: Type 2 alveolar epithelial (AT2) cells of the lung are fundamental in regulating alveolar inflammation in response to injury. Impaired mitochondrial long-chain fatty acid β-oxidation (mtLCFAO) in AT2 cells is assumed to aggravate alveolar inflammation… read more here.
Keywords: at2; mtlcfao; injury; at2 cells ... See more keywords
Let-7 restrains an epigenetic circuit in AT2 cells to prevent fibrogenic intermediates in pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59641-1
Abstract: MicroRNA-mediated post-transcriptional regulation of lung alveolar type 2 (AT2) and AT1 cell differentiation remains understudied. Here, we demonstrate that the let-7 miRNA family plays a homeostatic role in AT2 quiescence by preventing the uncontrolled accumulation… read more here.
Keywords: let restrains; at2; pulmonary fibrosis; at2 cells ... See more keywords
Modeling functional responses to pollutant exposure using modular hydrogel supported vascularized alveolosphere-on-a-chip
Sign Up to like & getrecommendations! Published in 2025 at "Biomaterials Science"
DOI: 10.1039/d5bm00552c
Abstract: Alveolar type 2 (AT2) cells play a pivotal role in maintaining lung homeostasis, and the generation of three-dimensional cultures, such as alveolospheres, provides a valuable model for studying lung development, pathologies, and drug responses. Here,… read more here.
Keywords: matrix; vascularized alveolosphere; at2 cells; alveolosphere chip ... See more keywords
MDH1 and MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/2023500
Abstract: Background Acute lung injury (ALI) is a clinical disease with high morbidity and mortality, with limited treatment means. For primary alveolar epithelial type II (AT2) cells, glycolysis is an essential bioenergetic process. However, the significance… read more here.
Keywords: cell; at2 cells; mdh1 mdh2;
"Dr. Jekyll and Mr. Hyde": AT2 Cells in Lung Regeneration and Tumor Development.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-25-1177
Abstract: Alveolar type II (AT2) cells, the primary stem cell population in the distal lung epithelium, are known to be the most common cell of origin for lung adenocarcinoma (LUAD). A recent study published in Cell… read more here.
Keywords: cell; jekyll hyde; at2 cells; lung regeneration ... See more keywords
Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202001-0179le
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a coronavirus identified as the cause of an outbreak of coronavirus disease (COVID-19), which now causes death in over 6% of infected individuals worldwide (1–5). Patients with… read more here.
Keywords: expression; receptor; at2 cells; cell ... See more keywords
Idiopathic Pulmonary Fibrosis and Lung Cancer: Finding Similarities within Differences
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2019-0172ed
Abstract: Idiopathic pulmonary fibrosis (IPF) and non–small cell lung cancer (NSCLC) share important risk factors, including advanced age and cigarette smoking. Moreover, evidence of the efficacy of nintedanib, a small-molecule tyrosine kinase inhibitor, for slowing the… read more here.
Keywords: lung cancer; cancer; at2 cells; cell ... See more keywords
Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.159331
Abstract: Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are among the most common symptoms in patients with COVID-19 after hospital discharge. In mechanically ventilated patients with acute respiratory distress syndrome (ARDS) secondary to… read more here.
Keywords: lung; hypercapnia; at2 cells; catenin signaling ... See more keywords
Co-culture of human AT2 cells with fibroblasts reveals a MUC5B phenotype: insights from an organoid model
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Medicine"
DOI: 10.1186/s10020-024-00990-w
Abstract: Impaired interaction of fibroblasts with pneumocytes contributes to the progression of chronic lung disease such as idiopathic pulmonary fibrosis (IPF). Mucin 5B (MUC5B) is associated with IPF. Here we analyzed the interaction of primary fibroblasts… read more here.
Keywords: culture; at2 cells; culture human; muc5b ... See more keywords
Short-term intermittent cigarette smoke exposure enhances alveolar type 2 cell stemness via fatty acid oxidation
Sign Up to like & getrecommendations! Published in 2022 at "Respiratory Research"
DOI: 10.1186/s12931-022-01948-4
Abstract: Background Cigarette smoke (CS) is associated with chronic obstructive pulmonary disease (COPD) and cancer. However, the underlying pathological mechanisms are not well understood. We recently reported that mice exposed to long-term intermittent CS for 3 months… read more here.
Keywords: at2 cells; intermittent; exposure; cell ... See more keywords