Pulmonary alveolar regeneration in adult COVID-19 patients
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DOI: 10.1038/s41422-020-0369-7
Abstract: Dear Editor, Alveolar regeneration after an acute lung injury has been observed in many mammals. Results in animal models have shown that alveolar type II (AT2) cells function as resident alveolar stem cells that can… read more here.
Keywords: alveolar regeneration; at2 cells; at1 cells; at2 ... See more keywords
MDH1 and MDH2 Promote Cell Viability of Primary AT2 Cells by Increasing Glucose Uptake
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DOI: 10.1155/2022/2023500
Abstract: Background Acute lung injury (ALI) is a clinical disease with high morbidity and mortality, with limited treatment means. For primary alveolar epithelial type II (AT2) cells, glycolysis is an essential bioenergetic process. However, the significance… read more here.
Keywords: cell; at2 cells; mdh1 mdh2;
Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Respiratory and Critical Care Medicine"
DOI: 10.1164/rccm.202001-0179le
Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a coronavirus identified as the cause of an outbreak of coronavirus disease (COVID-19), which now causes death in over 6% of infected individuals worldwide (1–5). Patients with… read more here.
Keywords: expression; receptor; at2 cells; cell ... See more keywords
Idiopathic Pulmonary Fibrosis and Lung Cancer: Finding Similarities within Differences
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DOI: 10.1165/rcmb.2019-0172ed
Abstract: Idiopathic pulmonary fibrosis (IPF) and non–small cell lung cancer (NSCLC) share important risk factors, including advanced age and cigarette smoking. Moreover, evidence of the efficacy of nintedanib, a small-molecule tyrosine kinase inhibitor, for slowing the… read more here.
Keywords: lung cancer; cancer; at2 cells; cell ... See more keywords
Hypercapnia alters stroma-derived Wnt production to limit β-catenin signaling and proliferation in AT2 cells
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DOI: 10.1172/jci.insight.159331
Abstract: Persistent symptoms and radiographic abnormalities suggestive of failed lung repair are among the most common symptoms in patients with COVID-19 after hospital discharge. In mechanically ventilated patients with acute respiratory distress syndrome (ARDS) secondary to… read more here.
Keywords: lung; hypercapnia; at2 cells; catenin signaling ... See more keywords
Short-term intermittent cigarette smoke exposure enhances alveolar type 2 cell stemness via fatty acid oxidation
Sign Up to like & getrecommendations! Published in 2022 at "Respiratory Research"
DOI: 10.1186/s12931-022-01948-4
Abstract: Background Cigarette smoke (CS) is associated with chronic obstructive pulmonary disease (COPD) and cancer. However, the underlying pathological mechanisms are not well understood. We recently reported that mice exposed to long-term intermittent CS for 3 months… read more here.
Keywords: at2 cells; intermittent; exposure; cell ... See more keywords