Cardioprotective effect of thyroid hormone is mediated by AT2 receptor and involves nitric oxide production via Akt activation in mice
Sign Up to like & getrecommendations! Published in 2017 at "Heart and Vessels"
DOI: 10.1007/s00380-017-1101-5
Abstract: Studies have demonstrated that thyroid hormone (T3) can precondition the heart against ischaemic injury and improve post-ischaemic recovery. This study investigated whether the AT2 receptor (AT2R) is involved in cardioprotection and the potential molecular mechanism… read more here.
Keywords: at2 receptor; production; effect; mice ... See more keywords
AT2 Receptor Stimulation Inhibits Vascular Smooth Muscle Cell Senescence Induced by Angiotensin II and Hyperglycemia.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of hypertension"
DOI: 10.1093/ajh/hpac083
Abstract: BACKGROUND Hyperglycemia has been widely reported to induce vascular senescence. We have previously demonstrated that angiotensin II (Ang II) could promote brain vascular smooth muscle cell (VSMC) senescence, and its type 2 (AT2) receptor deletion… read more here.
Keywords: at2 receptor; senescence; vascular smooth; hyperglycemia ... See more keywords
[OP.7C.05] ANGIOTENSIN AT2 RECEPTOR AGONIST, COMPOUND 21, PREVENTS ABDOMINAL AORTIC ANEURYSM PROGRESSION AND THE DECREASE OF AORTIC WALL DISTENSIBILITY IN THE RAT
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000523164.52997.5d
Abstract: Objective: We studied the effects of selective AT2 receptor agonist, compound 21, (C21) treatment on experimental abdominal aortic aneurysm (AAA) formation in rats. Design and method: AAA was induced by perfusion of isolated aortic segments… read more here.
Keywords: at2 receptor; receptor agonist; distensibility; c21 ... See more keywords
A11971 Angiotensin II AT2 Receptor Decreases AT1 Receptor Expression and Function via NO/cGMP/Sp1 in Renal Proximal Tubule Cells from Wistar-Kyoto Rats
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548256.82096.b3
Abstract: Objectives: In the kidney, activation of the AT1 receptor increases renal sodium reabsorption, whereas the AT2 receptor produces the opposite effect. We hypothesized that the AT2 receptor regulates AT1 receptor expression and function in the… read more here.
Keywords: receptor; at2 receptor; receptor expression; at1 receptor ... See more keywords
Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002675
Abstract: ABSTRACT Translation of promising preclinical efficacy data for investigational analgesics to positive clinical trial outcomes is limited, despite the large collective effort to date. However, one target with positive proof-of-concept clinical trial data is the… read more here.
Keywords: at2 receptor; concept clinical; ema401; trial ... See more keywords
Angiotensin II induces apoptosis of human right and left ventricular endocardial endothelial cells by activating the AT2 receptor 1.
Sign Up to like & getrecommendations! Published in 2019 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2018-0592
Abstract: Endocardial endothelial cells (EECs) form a monolayer lining the ventricular cavities. Studies from our laboratory and the literature have shown differences between EECs isolated from the right and left ventricles (EECRs and EECLs, respectively). Angiotensin… read more here.
Keywords: at2 receptor; apoptosis; right left; endothelial cells ... See more keywords
Novel Pharmacology Following Heteromerization of the Angiotensin II Type 2 Receptor and the Bradykinin Type 2 Receptor
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.848816
Abstract: The angiotensin type 2 (AT2) receptor and the bradykinin type 2 (B2) receptor are G protein-coupled receptors (GPCRs) that have major roles in the cardiovascular system. The two receptors are known to functionally interact at… read more here.
Keywords: pharmacology; receptor; at2 receptor; type receptor ... See more keywords