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   Articles with "atc cells" as a keyword



Capsaicin inhibits the stemness of anaplastic thyroid carcinoma cells by triggering autophagy‐lysosome mediated OCT4A degradation

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recommendations! Published in 2022 at "Phytotherapy Research"

DOI: 10.1002/ptr.7361

Abstract: Capsaicin (CAP) is a well‐known anti‐cancer agent. Recently, we reported capsaicin‐induced apoptosis in anaplastic thyroid cancer (ATC) cells. It is well accepted that the generation of cancer stem cells (CSCs) is responsible for the dedifferentiation… read more here.

Keywords: cap; degradation; anaplastic thyroid; capsaicin ... See more keywords

Antimalarial drug artesunate is effective against chemoresistant anaplastic thyroid carcinoma via targeting mitochondrial metabolism

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recommendations! Published in 2020 at "Journal of Bioenergetics and Biomembranes"

DOI: 10.1007/s10863-020-09824-w

Abstract: Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid malignancies and resistant to chemotherapy. Novel therapeutic strategy is required for better management of ATC. In this work, we show that artesunate, an antimalarial… read more here.

Keywords: anaplastic thyroid; antimalarial drug; thyroid carcinoma; atc cells ... See more keywords

GAB1 is upregulated to promote anaplastic thyroid cancer cell migration through AKT-MDR1.

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recommendations! Published in 2022 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2022.03.101

Abstract: Anaplastic thyroid carcinoma (ATC) represents an undifferentiated, aggressive and highly metastatic form of thyroid cancer with high mortality. GAB1, through direct interaction with the kinase PI3K and phosphatase SHP2, is tightly involved in the activation… read more here.

Keywords: gab1; migration invasion; thyroid cancer; migration ... See more keywords

ENO2 promotes anoikis resistance in anaplastic thyroid cancer by maintaining redox homeostasis

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recommendations! Published in 2024 at "Gland Surgery"

DOI: 10.21037/gs-24-44

Abstract: Background Anoikis presents a significant barrier in the metastasis of cancer. As the most aggressive type of thyroid cancer, anaplastic thyroid cancer (ATC) exhibits a high risk of metastasis and is characterized by high mortality.… read more here.

Keywords: thyroid cancer; eno2; anoikis resistance; atc cells ... See more keywords