Capsaicin inhibits the stemness of anaplastic thyroid carcinoma cells by triggering autophagy‐lysosome mediated OCT4A degradation
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DOI: 10.1002/ptr.7361
Abstract: Capsaicin (CAP) is a well‐known anti‐cancer agent. Recently, we reported capsaicin‐induced apoptosis in anaplastic thyroid cancer (ATC) cells. It is well accepted that the generation of cancer stem cells (CSCs) is responsible for the dedifferentiation… read more here.
Keywords: cap; degradation; anaplastic thyroid; capsaicin ... See more keywords
Antimalarial drug artesunate is effective against chemoresistant anaplastic thyroid carcinoma via targeting mitochondrial metabolism
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DOI: 10.1007/s10863-020-09824-w
Abstract: Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid malignancies and resistant to chemotherapy. Novel therapeutic strategy is required for better management of ATC. In this work, we show that artesunate, an antimalarial… read more here.
Keywords: anaplastic thyroid; antimalarial drug; thyroid carcinoma; atc cells ... See more keywords
GAB1 is upregulated to promote anaplastic thyroid cancer cell migration through AKT-MDR1.
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DOI: 10.1016/j.bbrc.2022.03.101
Abstract: Anaplastic thyroid carcinoma (ATC) represents an undifferentiated, aggressive and highly metastatic form of thyroid cancer with high mortality. GAB1, through direct interaction with the kinase PI3K and phosphatase SHP2, is tightly involved in the activation… read more here.
Keywords: gab1; migration invasion; thyroid cancer; migration ... See more keywords