Arginyl‐tRNA‐protein transferase 1 (ATE1) promotes melanoma cell growth and migration
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14376
Abstract: Arginyl‐tRNA‐protein transferase 1 (ATE1) catalyses N‐terminal protein arginylation, a post‐translational modification implicated in cell migration, invasion and the cellular stress response. Herein, we report that ATE1 is overexpressed in NRAS‐mutant melanomas, while it is downregulated… read more here.
Keywords: cell; arginyl trna; melanoma cell; ate1 ... See more keywords
Ablation of arginyl-tRNA-protein transferase in oligodendrocytes impairs central nervous system myelination.
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24107
Abstract: Addition of arginine (Arg) from tRNA can cause major alterations of structure and function of protein substrates. This post-translational modification, termed protein arginylation, is mediated by the enzyme arginyl-tRNA-protein transferase 1 (Ate1). Arginylation plays essential… read more here.
Keywords: trna protein; arginyl trna; protein transferase; myelination ... See more keywords
Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.08.027
Abstract: Arginylation is an emerging protein modification mediated by arginyltransferase ATE1, shown to regulate embryogenesis and actin cytoskeleton, however its functions in different physiological systems are not well understood. Here we analyzed the role of ATE1… read more here.
Keywords: growth cones; brain; neurite outgrowth; ate1 ... See more keywords
Reduced Arginyltransferase 1 is a driver and a potential prognostic indicator of prostate cancer metastasis
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DOI: 10.1038/s41388-018-0462-2
Abstract: Most prostate cancer cases remain indolent for long periods of time, but metastatic progression quickly worsens the prognosis and leads to mortality. However, little is known about what promotes the metastasis of prostate cancer and… read more here.
Keywords: cancer; cancer metastasis; prostate cancer; ate1 ... See more keywords