Results of a Dose‐Finding Phase 1b Study of Subcutaneous Atezolizumab in Patients With Locally Advanced or Metastatic Non–Small Cell Lung Cancer
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DOI: 10.1002/cpdd.936
Abstract: Intravenous (IV) atezolizumab is approved for non–small cell lung and other cancers. Subcutaneous (SC) atezolizumab coformulated with recombinant human hyaluronidase, a permeation enhancer for SC dispersion and absorption, is being developed to improve treatment options,… read more here.
Keywords: phase; cell lung; atezolizumab; every weeks ... See more keywords
A Pretargeted Imaging Strategy for Immune Checkpoint Ligand PD-L1 Expression in Tumor Based on Bioorthogonal Diels-Alder Click Chemistry
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-019-01441-3
Abstract: Purpose The use of antibodies as tracers requires labeling with isotopes with long half-lives due to their slow pharmacokinetics, which creates prohibitively high radiation dose to non-target organs. Pretargeted methodology could avoid the high radiation… read more here.
Keywords: 99m hynic; hynic peg; chemistry; atezolizumab ... See more keywords
Atezolizumab (in Combination with Nab-Paclitaxel): A Review in Advanced Triple-Negative Breast Cancer
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DOI: 10.1007/s40265-020-01295-y
Abstract: Atezolizumab (Tecentriq ® ), an immune checkpoint inhibitor against programmed death ligand 1 (PD-L1), is the first immunotherapy agent to be approved (for use in combination with nab-paclitaxel) in the USA, the EU (as first-line)… read more here.
Keywords: nab paclitaxel; combination nab; advanced triple; plus nab ... See more keywords
Bladder cancer: Atezolizumab: an alternative to cisplatin?
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DOI: 10.1038/nrurol.2016.271
Abstract: Cisplatin-based chemotherapy is an effective first-line treatment of patients with locally advanced or metastatic urothelial carcinoma; however, many patients are ineligible to receive cisplatin, and other types of chemotherapy, although better tolerated, are not as… read more here.
Keywords: alternative cisplatin; trial; treatment; cisplatin ... See more keywords
Both T cell priming in lymph node and CXCR3-dependent migration are the key events for predicting the response of atezolizumab
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-93113-y
Abstract: Anti-PD-L1 antibodies benefit many cancer patients, even those with “non-inflamed tumor”. Determining which patients will benefit remains an important clinical goal. In a non-inflamed tumor mouse model, we found that PD-L1 was highly expressed on… read more here.
Keywords: cxcr3; response; atezolizumab; cell priming ... See more keywords
Evaluation of atezolizumab immunogenicity: Clinical pharmacology (part 1).
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and translational science"
DOI: 10.1111/cts.13127
Abstract: Baseline patient characteristics and prognostic factors are important considerations in oncology when evaluating the impact of immunogenicity on pharmacokinetics (PK) and efficacy. Here, we assessed the impact of anti-drug antibodies (ADA) on the PK of… read more here.
Keywords: immunogenicity; ada; exposure; pharmacology ... See more keywords
Safety, Clinical Activity, and Biological Correlates of Response in Patients with Metastatic Melanoma: Results from a Phase I Trial of Atezolizumab
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DOI: 10.1158/1078-0432.ccr-18-3488
Abstract: Purpose: Atezolizumab [anti–programmed death-ligand 1 (PD-L1)] selectively targets PD-L1 to block its interaction with receptors programmed death 1 and B7.1, thereby reinvigorating antitumor T-cell activity. We evaluated the long-term safety and activity of atezolizumab, along… read more here.
Keywords: response; clinical activity; activity; atezolizumab ... See more keywords
Safety, Clinical Activity, and Biological Correlates of Response in Patients with Metastatic Melanoma: Results from a Phase I Trial of Atezolizumab—Response
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-20-0298
Abstract: The assertion of Goldstein and colleagues that lower or less frequent atezolizumab dosingmay be therapeutically effective is based onmean steady-state drug concentration data. However, a general consideration in determining the recommended dose is to ensure… read more here.
Keywords: response; activity; majority patients; atezolizumab ... See more keywords
Abstract OT2-07-03: IMpassion031: A phase III study comparing neoadjuvant atezolizumab vs placebo in combination with nab-paclitaxel–based chemotherapy in early triple-negative breast cancer (TNBC)
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DOI: 10.1158/1538-7445.sabcs17-ot2-07-03
Abstract: Background Atezolizumab is an anti–programmed death-ligand 1 (PD-L1) monoclonal antibody that blocks the binding of PD-L1 to PD-1 and B7.1 receptors, thereby restoring tumor-specific immunity. TNBC is characterized by PD-L1 expression on tumor-infiltrating immune cells… read more here.
Keywords: nab paclitaxel; placebo; breast cancer; tnbc ... See more keywords
Atezolizumab and Bevacizumab in Patients with Unresectable Hepatocellular Carcinoma: Pharmacokinetic and Safety Assessments Based on Hepatic Impairment Status and Geographic Region
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DOI: 10.1159/000515817
Abstract: Introduction: Phase 1b GO30140 and phase 3 IMbrave150 studies evaluated first-line atezolizumab + bevacizumab for unresectable hepatocellular carcinoma (HCC). Here, we evaluated pharmacokinetics (PK) and safety by hepatic impairment status and geographic region. Methods: Patients… read more here.
Keywords: bevacizumab; hepatic impairment; impairment status; impairment ... See more keywords
Atezolizumab-associated encephalitis in metastatic lung adenocarcinoma: a case report
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DOI: 10.1186/s13256-020-02411-y
Abstract: Background In recent years, immune checkpoint inhibitors have been widely used as a crucial therapy in malignant tumors. Immune checkpoint inhibitors can cause various autoimmune side effects called immune-related adverse events because they generate an… read more here.
Keywords: immune checkpoint; case; atezolizumab; encephalitis ... See more keywords