Analyzing the impact of ATF3 in tumorigenesis and immune cell infiltration of ovarian tumor: a bioinformatics study
Sign Up to like & getrecommendations! Published in 2021 at "Medical Oncology"
DOI: 10.1007/s12032-021-01541-7
Abstract: ATF3 is an essential transcription activator in regulating cancer-related genetic expression. To identify the role of ATF3 in ovarian tumor, we investigated the correlation between ATF3 expression and the clinicopathological properties using multiple database. The… read more here.
Keywords: cell; infiltration; atf3; expression ... See more keywords
Atf3 induction is a therapeutic target for obesity and metabolic diseases.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.09.048
Abstract: Activating transcription factor 3 (Atf3) has been previously demonstrated to impact obesity and metabolism. However, a metabolic role of Atf3 in mice remains debatable. We investigated the role of Atf3 in mice and further investigated… read more here.
Keywords: metabolic diseases; atf3; obesity metabolic; obesity ... See more keywords
The cardiac maladaptive ATF3-dependent cross-talk between cardiomyocytes and macrophages is mediated by the IFNγ-CXCL10-CXCR3 axis.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2016.11.159
Abstract: RATIONAL Pressure overload induces adaptive and maladaptive cardiac remodeling processes in the heart. Part of the maladaptive process is the cross-talk between cardiomyocytes and macrophages which is dependent on the function of the Activating Transcription… read more here.
Keywords: cross talk; cxcr3; cardiomyocytes macrophages; cardiac remodeling ... See more keywords
Activating transcription factor 3 protects mice against pseudomonas aeruginosa-induced acute lung injury by interacting with lipopolysaccharide binding protein.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular immunology"
DOI: 10.1016/j.molimm.2017.06.037
Abstract: Excessive inflammatory response is critical event in the pathogenesis of acute lung injury (ALI). Previous study has shown that activating transcription factor 3 (ATF3) plays a role in downregulate inflammatory responses including ventilation-induced ALI. We… read more here.
Keywords: atf3; mice; lung injury; acute lung ... See more keywords
Atf3 defines a population of pulmonary endothelial cells essential for lung regeneration
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.10.14.512212
Abstract: Following acute injury, the capillary vascular bed in the lung must be repaired to reestablish gas exchange with the external environment. Little is known about the transcriptional and signaling factors that drive pulmonary endothelial cell… read more here.
Keywords: regeneration; pulmonary endothelial; lung; atf3 ... See more keywords
Transcription factor ATF3 mediates the radioresistance of breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13688
Abstract: This study was designed to research the influence of activating transcription factor 3 (ATF3) on the radioresistance of breast cancer. ATF3 expression was measured by qRT‐PCR and immunohistochemistry. Cancerous cell lines were cultured in vitro,… read more here.
Keywords: atf3; radioresistance breast; breast cancer;
Leishmania donovani Targets Host Transcription Factor NRF2 To Activate Antioxidant Enzyme HO-1 and Transcriptional Repressor ATF3 for Establishing Infection
Sign Up to like & getrecommendations! Published in 2021 at "Infection and Immunity"
DOI: 10.1128/iai.00764-20
Abstract: We showed previously that antioxidant enzyme heme oxygenase 1 (HO-1) is critical for Leishmania survival in visceral leishmaniasis. HO-1 inhibits host oxidative burst and inflammatory cytokine production, leading to parasite persistence. ABSTRACT We showed previously… read more here.
Keywords: infection; antioxidant enzyme; atf3; transcription ... See more keywords
ATF3 Coordinates Antitumor Synergy between Epigenetic Drugs and Protein Disulfide Isomerase Inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-4046
Abstract: This study uses a first-in-class PDI inhibitor entering clinical development to enhance the effects of epigenetic drugs in some of the deadliest forms of cancer. Histone deacetylase inhibitors (HDACi) are largely ineffective in the treatment… read more here.
Keywords: protein disulfide; epigenetic drugs; cancer; pdi ... See more keywords
Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta
Sign Up to like & getrecommendations! Published in 2017 at "Hypertension"
DOI: 10.1161/hypertensionaha.117.09548
Abstract: Preeclampsia is a major pregnancy complication associated with poor placental perfusion and placental hypoxia. Systemic and placental inflammation and elevated placental secretion of the antiangiogenic factors sFlt-1 (soluble fms-like tyrosine kinase 1) and sEng (soluble… read more here.
Keywords: preeclamptic placentas; atf3; soluble fms; factor ... See more keywords
JUN and ATF3 Regulate the Transcriptional Output of the Unfolded Protein Response to Support Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-119742
Abstract: The genomic alterations that drive acute myeloid leukemia (AML) are well established, however, the molecular pathways that are deregulated as a consequence of these mutations and their impact on AML development and progression remain poorly… read more here.
Keywords: jun atf3; jun; inhibition; atf3 ... See more keywords
ATF3 modulates the proliferation, migration, and apoptosis of synovial fibroblasts after arthroscopy by promoting RGS1 transcription.
Sign Up to like & getrecommendations! Published in 2023 at "Current molecular medicine"
DOI: 10.2174/1566524023666230417084150
Abstract: BACKGROUND Osteoarthritis (OA) is a degenerative joint disease involving both cartilage and synovium. Activating transcription factor 3 (ATF3) and regulator of G protein signaling 1 (RGS1) have been reported to be up-regulated in OA. However,… read more here.
Keywords: proliferation migration; apoptosis; rgs1; atf3 ... See more keywords