RASSF1 is identified by transcriptome coordination analysis as a target of ATF4
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13569
Abstract: Evaluation of gene co‐regulation is a powerful approach for revealing regulatory associations between genes and predicting biological function, especially in genetically diverse samples. Here, we applied this strategy to identify transcripts that are co‐regulated with… read more here.
Keywords: coordination analysis; atf4; rassf1; rassf1 identified ... See more keywords
Silencing ATF4 inhibits JMJD3-dependent JUNB/ETS1 axis and mitigates cerebral ischemic injury.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23070
Abstract: Activating transcription factor 4 (ATF4) is known to play an important role in cerebral ischemia through apoptosis and neuron regulation. Histone demethylase JMJD3, specifically removing the methylation of H3K27me3, is highlighted to attenuate cerebral ischemic… read more here.
Keywords: expression; jmjd3; atf4; ischemic injury ... See more keywords
ATF4 Regulates MYB to Increase γ-Globin in Response to Loss of β-Globin.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107993
Abstract: β-Hemoglobinopathies can trigger rapid production of red blood cells in a process known as stress erythropoiesis. Cellular stress prompts differentiating erythroid precursors to express high levels of fetal γ-globin. However, the mechanisms underlying γ-globin production… read more here.
Keywords: globin; response; atf4; stress ... See more keywords
ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.146
Abstract: Activating transcription factor 4 (ATF4) is a critical mediator of metabolic and oxidative homeostasis and cell survival. ATF4 is elevated in response to diverse microenvironmental stresses, including starvation, ER stress damages and exposure to toxic… read more here.
Keywords: cell; atf4; neuronal cell; xct dependent ... See more keywords
A novel secretagogin/ATF4 pathway is involved in oxidized LDL-induced endoplasmic reticulum stress and islet β-cell apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Acta biochimica et biophysica Sinica"
DOI: 10.1093/abbs/gmaa142
Abstract: Excessive accumulation of cholesterol in β cells initiates endoplasmic reticulum (ER) stress and associated apoptosis. We have reported that excessive uptake of cholesterol by MIN6 cells decreases the expression of secretagogin (SCGN) and then attenuates… read more here.
Keywords: apoptosis; atf4; cell apoptosis; scgn ... See more keywords
TGF-β Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of respiratory cell and molecular biology"
DOI: 10.1165/rcmb.2020-0143oc
Abstract: Idiopathic pulmonary fibrosis is a fatal disease characterized by the TGF-β-dependent differentiation of lung fibroblasts into myofibroblasts, leading to excessive deposition of collagen proteins and progressive scarring. We have previously shown that synthesis of collagen… read more here.
Keywords: activation; lung fibroblasts; atf4; metabolic reprogramming ... See more keywords
Targeted Deletion of ATF4 in ß Cells Leads to the Vulnerability and Dedifferentiation during ER Stress
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-2104-p
Abstract: ATF4 is the main transcriptional regulator of the Unfolded Protein Response (UPR) that promote restoration of normal ER function, although the contribution of ATF4 on β-cells remains poorly understood. Therefore, we developed mature β-cell specific… read more here.
Keywords: atf4; atf4 cells; stress; none ... See more keywords
Isoproterenol Increases RANKL Expression in a ATF4/NFATc1-Dependent Manner in Mouse Osteoblastic Cells
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18102204
Abstract: Sympathetic nervous system stimulation-induced β-adrenergic signal transduction is known to induce bone loss and increase of osteoclast activity. Although isoproterenol, a nonspecific β-adrenergic receptor agonist, has been shown to increase receptor activator of NF-κB ligand… read more here.
Keywords: atf4 nfatc1; isoproterenol; atf4; isoproterenol induced ... See more keywords
TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415705
Abstract: Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by fibroblast activation, excessive deposition of extracellular matrix, and progressive scarring; the pathogenesis remains elusive. The present study explored the role of Tribbles pseudokinase… read more here.
Keywords: ipf; atf4; fibroblast activation; trib3 ... See more keywords