Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2018.03.011
Abstract: Lipotoxicity plays an important role in the progression of chronic kidney damage via various mechanisms, such as endoplasmic reticulum stress. Several studies proposed renal lipotoxicity in glomerular and tubular cells but the effect of lipid… read more here.
Keywords: production; endoplasmic reticulum; palmitate; atf4 activation ... See more keywords
Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00429
Abstract: Toxicological responses to chemical insult are largely regulated by transcriptionally activated pathways that may be independent, correlated and partially or fully overlapping. Investigating the dynamics of the interactions between stress responsive transcription factors from toxicogenomic… read more here.
Keywords: ahr atf4; investigation nrf2; activation toxicogenomic; atf4 activation ... See more keywords