ATF4-mediated stress response as a therapeutic vulnerability in chordoma.
Sign Up to like & getrecommendations! Published in 2025 at "Molecular oncology"
DOI: 10.1002/1878-0261.70176
Abstract: Chordoma, a rare primary bone malignancy, currently lacks effective targeted therapies. Despite surgical resection and adjuvant radiotherapy, prognosis remains poor. Recent preclinical studies have highlighted potential therapeutic targets, including the transcription factor T-box transcription factor… read more here.
Keywords: stress response; atf4 mediated; chordoma; mediated stress ... See more keywords
2,3,5,6-Tetramethylpyrazine protects retinal photoreceptors against endoplasmic reticulum stress by modulating ATF4-mediated inhibition of PRP aggregation.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-020-02017-3
Abstract: Endoplasmic reticulum (ER) stress is a common threat to photoreceptors during the pathogenesis of chronic retinopathies and often results in irreversible visual impairment. 2,3,5,6-Tetramethylpyrazine (TMP), which possesses many beneficial pharmacological activities, is a potential drug… read more here.
Keywords: prp aggregation; atf4 mediated; stress; mediated inhibition ... See more keywords