TCA cycle off, ATF4 on for metabolic homeostasis.
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DOI: 10.1016/j.tibs.2022.03.006
Abstract: Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of… read more here.
Keywords: atf4 metabolic; cycle; tca cycle; cycle atf4 ... See more keywords