Salubrinal Regulates the Apoptosis of Adrenocortical Carcinoma Cells via the PERK/eIF2α/ATF4 Signaling Pathway
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Endocrinology"
DOI: 10.1155/2021/5038130
Abstract: The protein-kinase-R- (PKR-) like endoplasmic reticulum kinase (PERK) signaling pathway is a well-known promoter of cell apoptosis. In this study, we aimed to determine whether salubrinal (Sal), a selective activator of eukaryotic translation initiation factor… read more here.
Keywords: eif2 atf4; eif2; atf4 signaling; perk eif2 ... See more keywords
TGFBR3 supports anoikis through suppressing ATF4 signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.258396
Abstract: Epithelial morphogenesis and oncogenic transformation can cause loss of cell adhesion, and detached cells are eliminated by anoikis. Here, we reveal that transforming growth factor beta receptor 3 (TGFBR3) acts as an anoikis mediator through… read more here.
Keywords: atf4 signaling; supports anoikis; suppressing atf4; anoikis suppressing ... See more keywords