The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1770-2
Abstract: Activating transcription factor-5 (ATF5) is a stress-response transcription factor induced upon different cell stressors like fasting, amino-acid limitation, cadmium or arsenite. ATF5 is also induced, and promotes transcription of anti-apoptotic target genes like MCL1, during… read more here.
Keywords: atf5; transcription; polyglutamine; transcription factor ... See more keywords
ATF5 deficiency causes abnormal cortical development
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DOI: 10.1038/s41598-021-86442-5
Abstract: Activating transcription factor 5 (ATF5) is a member of the cAMP response element binding protein (CREB)/ATF family of basic leucine zipper transcription factors. We previously reported that ATF5-deficient (ATF5−/−) mice exhibited behavioural abnormalities, including abnormal… read more here.
Keywords: atf5; atf5 mice; cortical development; atf5 deficiency ... See more keywords
Effect of AAV-mediated overexpression of ATF5 and downstream targets of an integrated stress response in murine skeletal muscle
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DOI: 10.1038/s41598-021-99432-4
Abstract: We previously reported that growth promoter-induced skeletal muscle hypertrophy co-ordinately upregulated expression of genes associated with an integrated stress response (ISR), as well as potential ISR regulators. We therefore used Adeno-Associated Virus (AAV)-mediated overexpression of… read more here.
Keywords: atf5; aav; skeletal muscle; overexpression ... See more keywords