Thrombospondin 1 Promotes Endoplasmic Reticulum Stress and Apoptosis in HK-2 Cells by Upregulating ATF6-CHOP
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DOI: 10.1007/s11596-022-2513-8
Abstract: The goal of this study is to investigate the role and mechanism of endoplasmic reticulum stress and apoptosis regulated by thrombospondin 1 (TSP1) in human renal tubular epithelial cells (HK-2 cells). HK-2 cells were exposed… read more here.
Keywords: reticulum stress; endoplasmic reticulum; apoptosis; reticulum ... See more keywords
Activation of the UPR sensor ATF6α is regulated by its redox-dependent dimerization and ER retention by ERp18
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122657119
Abstract: Significance Membrane and secretory proteins are synthesized in the endoplasmic reticulum (ER). Perturbations to ER function disrupts protein folding, causing misfolded proteins to accumulate, a condition known as ER stress. Cells adapt to stress by… read more here.
Keywords: dimerization; retention; redox dependent; activation upr ... See more keywords
Loss of ATF6α in a human carcinoma cell line is compensated not by its paralogue ATF6β but by sustained activation of the IRE1 and PERK arms for tumor growth in nude mice
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-07-0292
Abstract: To survive poor nutritional conditions, tumor cells activate the unfolded protein response, which is composed of the IRE1, PERK, and ATF6 arms, to maintain the homeostasis of the endoplasmic reticulum, where secretory and transmembrane proteins… read more here.
Keywords: nude mice; atf6; ire1 perk; perk arms ... See more keywords
THU0203 PROMOTER DNA METHYLATION AND HSA-MIR-424-5P REGULATE ATF6 ALPHA EXPRESSION IN SALIVARY GLANDS OF PATIENTS WITH SJÖGREN’S SYNDROME
Sign Up to like & getrecommendations! Published in 2019 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2019-eular.4712
Abstract: Background: Salivary glands (SG) from Sjögren’s syndrome (SS)-patients show chronic inflammation and endoplasmic reticulum (ER) stress. To counteract ER stress, eukaryotic cells activate adaptive mechanisms referred to as the unfolded protein response via sensors present… read more here.
Keywords: methylation; mir 424; dna; hsa mir ... See more keywords
Activating Transcription Factor 6 (ATF6) Modulates The Proteostatic Response To Mutant Surfactant Protein C Conformers In Alveolar Epithelial Cells
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DOI: 10.1152/physiol.2023.38.s1.5727024
Abstract: Alveolar Type II (AT2) epithelial cell dysfunction is a hallmark of the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF), a progressive interstitial lung disease. Mutations in the surfactant protein C (SP-C) gene (SFTPC) are a high… read more here.
Keywords: surfactant protein; expression; physiology; atf6 ... See more keywords
A lifetime of stress: ATF6 in development and homeostasis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-018-0453-1
Abstract: BackgroundActivating transcription factor 6 (ATF6) is an endoplasmic reticulum (ER)-localised protein and member of the leucine zipper family of transcription factors. Best known for its role in transducing signals linked to stress to the endoplasmic… read more here.
Keywords: homeostasis; atf6; tissue homeostasis; stress ... See more keywords
Normal tissue homeostasis and impairment of selective inflammatory responses in dendritic cells deficient for ATF6α
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1089728
Abstract: The initiation of adaptive immunity relies on the performance of dendritic cells (DCs), which are specialized leukocytes with professional antigen presenting capabilities. As such, the molecular mechanisms safeguarding DC homeostasis are matter of intense research.… read more here.
Keywords: role; biology; inflammatory; dendritic cells ... See more keywords
ATF6α contributes to rheumatoid arthritis by inducing inflammatory cytokine production and apoptosis resistance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.965708
Abstract: Objective The contribution of activating transcription factor 6α (ATF6α) in rheumatoid arthritis (RA) pathogenesis, especially on fibroblast-like synoviocytes (FLSs), has been suggested by its sensitivity to inflammatory stimulus. However, the exact role and therapeutic potential… read more here.
Keywords: cia; rheumatoid arthritis; arthritis; atf6 ... See more keywords
Myogenesis in C2C12 Cells Requires Phosphorylation of ATF6α by p38 MAPK
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11051457
Abstract: Activating transcription factor 6α (ATF6α) is an endoplasmic reticulum protein known to participate in unfolded protein response (UPR) during ER stress in mammals. Herein, we show that in mouse C2C12 myoblasts induced to differentiate, ATF6α… read more here.
Keywords: atf6; c2c12; myogenesis; p38 mapk ... See more keywords
Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21031134
Abstract: There are more than 2000 transcription factors in eukaryotes, many of which are subject to complex mechanisms fine-tuning their activity and their transcriptional programs to meet the vast array of conditions under which cells must… read more here.
Keywords: transcription; atf6; transcription factor; protein folding ... See more keywords