Rabbit antithymocyte globulin dose does not affect response or survival as first-line therapy for acquired aplastic anemia: a multicenter retrospective study
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3416-4
Abstract: In a prospective randomized study, treatment for aplastic anemia (AA) with rabbit antithymocyte globulin (r-ATG) and cyclosporine showed inferior hematological response and survival in comparison to horse antithymocyte globulin (h-ATG) and cyclosporine. However, h-ATG was… read more here.
Keywords: response; atg; response survival; antithymocyte globulin ... See more keywords
A comprehensive analysis of the major specificities of anti-human T lymphocyte porcine immunoglobulin (p-ATG)
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Hematology"
DOI: 10.1007/s00277-024-06028-9
Abstract: Anti-human T lymphocyte porcine immunoglobulin (p-ATG) is a potent immunosuppressive agent derived from porcine sources used in various immunotherapy applications. It is compared with similar products derived from other species, such as rabbit anti-thymocyte globulin… read more here.
Keywords: anti human; analysis; potency; atg ... See more keywords
The Effect of ATG Exposure Based on Recipient Absolute Lymphocyte Counts in Patients Undergoing Allo-HCT with ATG and Ptcy As Gvhd Prophylaxis
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.268
Abstract: Background Recent studies have shown that using absolute lymphocyte count (ALC) based dosing of ATG (anti-thymoglobulin) can improve survival after allogeneic hematopoietic cell transplantation (Allo–HCT). At our center we routinely use a combination of ATG + post-transplant… read more here.
Keywords: gvhd prophylaxis; atg; allo hct;
The Thioredoxin Reductase-1 Inhibitor Aurothioglucose Enhances Glutathione-dependent Antioxidant Responses in a Murine Model of Bronchopulmonary Dysplasia
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.048
Abstract: Introduction Therapeutic oxygen contributes to the development of bronchopulmonary dysplasia (BPD). The thioredoxin reductase-1 (TrxR1) inhibitor aurothioglucose (ATG) is protective in our murine BPD model. Improved lung structure in ATG-treated newborn mice was associated with… read more here.
Keywords: bronchopulmonary dysplasia; antioxidant responses; atg; gsh ... See more keywords
Textural evolution during high-pressure dehydration of serpentinite to peridotite and its relation to stress orientations and kinematics of subducting slabs: Insights from the Almirez ultramafic massif
Sign Up to like & getrecommendations! Published in 2018 at "Lithos"
DOI: 10.1016/j.lithos.2018.09.033
Abstract: Abstract The Almirez ultramafic massif (SE Spain) preserves the transformation of high-P antigorite (Atg-) serpentinite to chlorite (Chl-) harzburgite (1.6–1.9 GPa; 680–710 °C), a metamorphic reaction that is the primary source of water at the intermediate depth… read more here.
Keywords: orientation; atg; kinematics; stress ... See more keywords
IL-6 inhibition prevents costimulation blockade-resistant allograft rejection in T cell-depleted recipients by promoting intragraft immune regulation in mice
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48574-w
Abstract: The efficacy of costimulation blockade with CTLA4-Ig (belatacept) in transplantation is limited due to T cell-mediated rejection, which also persists after induction with anti-thymocyte globulin (ATG). Here, we investigate why ATG fails to prevent costimulation… read more here.
Keywords: blockade resistant; blockade; rejection; costimulation blockade ... See more keywords
Dual T-cell depletion with individually tailored anti-thymocyte globulin and attenuated dose of post-transplant cyclophosphamide in haploidentical peripheral stem cell transplantation
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-64361-5
Abstract: This study aimed to assess the efficacy of dual T-cell suppression using individually tailored doses of antithymocyte globulin (ATG) and attenuated dose of post-transplant cyclophosphamide (PTCy) in haploidentical hematopoietic stem cell transplantation (haplo-HSCT). We conducted… read more here.
Keywords: group; individually tailored; ptcy; cell ... See more keywords
ATG-Thymoglobulin Versus ATG-Fresenius for Conditioning in Thalassemia Patients Who Underwent Allogenic Stem Cell Transplantation from Matched-Sibling Donor: A Tertiary Cancer Care Center Short-Term Experience
Sign Up to like & getrecommendations! Published in 2024 at "Hemoglobin"
DOI: 10.1080/03630269.2024.2398244
Abstract: Abstract Graft rejection and Graft-versus-host disease (GVHD) are some of the significant factors resulting in morbidity and mortality following allogeneic hematopoietic cell transplantation. Prophylaxis for GVHD using T-cell depleting agents is helpful in reducing the… read more here.
Keywords: cell transplantation; group; cell; versus ... See more keywords
Bidirectional roles of the Ccr4-Not complex in regulating autophagy before and after nitrogen starvation
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2036476
Abstract: ABSTRACT Macroautophagy/autophagy is a highly conserved catabolic process by which cytoplasmic constituents are delivered to the vacuole/lysosome for degradation and recycling. To maintain cellular homeostasis and prevent pathologies, the induction and amplitude of autophagy activity… read more here.
Keywords: atg; regulating autophagy; starvation; ccr4 complex ... See more keywords
Low-dose post-transplant cyclophosphamide can mitigate GVHD and enhance the G-CSF/ATG induced GVHD protective activity and improve haploidentical transplant outcomes
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1356152
Abstract: ABSTRACT Use of high-dose, post-transplant cyclophosphamide (PTCy) results in low rates of graft-versus-host-disease (GVHD) and favorable immune reconstitution, although with higher rates of relapse and somewhat high rates of graft failure. We hypothesized that permissible… read more here.
Keywords: low dose; ptcy; atg; dose ptcy ... See more keywords
#1006 Basiliximab induction alone vs. a dual ATG-basiliximab approach in first living non-sensitized renal transplant recipients with reduced HLA matching
Sign Up to like & getrecommendations! Published in 2025 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfaf116.0803
Abstract: Individualizing induction therapy based on immunological risk is crucial for optimizing outcomes in kidney transplantation. Due to the prevalent utilization of living unrelated donor (LURD) transplants in Israel , a substantial proportion of non-sensitized recipients… read more here.
Keywords: non sensitized; basiliximab induction; hla matching; atg ... See more keywords