Rabbit antithymocyte globulin dose does not affect response or survival as first-line therapy for acquired aplastic anemia: a multicenter retrospective study
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3416-4
Abstract: In a prospective randomized study, treatment for aplastic anemia (AA) with rabbit antithymocyte globulin (r-ATG) and cyclosporine showed inferior hematological response and survival in comparison to horse antithymocyte globulin (h-ATG) and cyclosporine. However, h-ATG was… read more here.
Keywords: response; atg; response survival; antithymocyte globulin ... See more keywords
The Effect of ATG Exposure Based on Recipient Absolute Lymphocyte Counts in Patients Undergoing Allo-HCT with ATG and Ptcy As Gvhd Prophylaxis
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.268
Abstract: Background Recent studies have shown that using absolute lymphocyte count (ALC) based dosing of ATG (anti-thymoglobulin) can improve survival after allogeneic hematopoietic cell transplantation (Allo–HCT). At our center we routinely use a combination of ATG + post-transplant… read more here.
Keywords: gvhd prophylaxis; atg; allo hct;
The Thioredoxin Reductase-1 Inhibitor Aurothioglucose Enhances Glutathione-dependent Antioxidant Responses in a Murine Model of Bronchopulmonary Dysplasia
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.048
Abstract: Introduction Therapeutic oxygen contributes to the development of bronchopulmonary dysplasia (BPD). The thioredoxin reductase-1 (TrxR1) inhibitor aurothioglucose (ATG) is protective in our murine BPD model. Improved lung structure in ATG-treated newborn mice was associated with… read more here.
Keywords: bronchopulmonary dysplasia; antioxidant responses; atg; gsh ... See more keywords
Textural evolution during high-pressure dehydration of serpentinite to peridotite and its relation to stress orientations and kinematics of subducting slabs: Insights from the Almirez ultramafic massif
Sign Up to like & getrecommendations! Published in 2018 at "Lithos"
DOI: 10.1016/j.lithos.2018.09.033
Abstract: Abstract The Almirez ultramafic massif (SE Spain) preserves the transformation of high-P antigorite (Atg-) serpentinite to chlorite (Chl-) harzburgite (1.6–1.9 GPa; 680–710 °C), a metamorphic reaction that is the primary source of water at the intermediate depth… read more here.
Keywords: orientation; atg; kinematics; stress ... See more keywords
Bidirectional roles of the Ccr4-Not complex in regulating autophagy before and after nitrogen starvation
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2036476
Abstract: ABSTRACT Macroautophagy/autophagy is a highly conserved catabolic process by which cytoplasmic constituents are delivered to the vacuole/lysosome for degradation and recycling. To maintain cellular homeostasis and prevent pathologies, the induction and amplitude of autophagy activity… read more here.
Keywords: atg; regulating autophagy; starvation; ccr4 complex ... See more keywords
Low-dose post-transplant cyclophosphamide can mitigate GVHD and enhance the G-CSF/ATG induced GVHD protective activity and improve haploidentical transplant outcomes
Sign Up to like & getrecommendations! Published in 2017 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1356152
Abstract: ABSTRACT Use of high-dose, post-transplant cyclophosphamide (PTCy) results in low rates of graft-versus-host-disease (GVHD) and favorable immune reconstitution, although with higher rates of relapse and somewhat high rates of graft failure. We hypothesized that permissible… read more here.
Keywords: low dose; ptcy; atg; dose ptcy ... See more keywords
Improved GRFS after posttransplant cyclophosphamide-based vs ATG-based HLA-mismatched unrelated donor transplant
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022007596
Abstract: Abstract A common method to prevent graft-versus-host disease after allogeneic hematopoietic cell transplantation (HCT) from an HLA-mismatched unrelated donor (MMUD) is tacrolimus, methotrexate, and antithymocyte globulin (ATG). The use of posttransplant cyclophosphamide (PTCy) showed promise… read more here.
Keywords: mismatched unrelated; atg; unrelated donor; hla mismatched ... See more keywords
Reduced Risk of Chronic Graft-Versus-Host Disease (cGVHD) by Rabbit Anti-Thymocyte Globulin (ATG) in Patients Undergoing Matched Sibling Donor Transplantation in Hematological Malignancies
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Transplantation"
DOI: 10.12659/aot.937356
Abstract: Background With the addition of anti-thymocyte globulin (ATG) to GVHD prophylaxis in patients undergoing transplantation of peripheral blood stem cells (PBSCT), the incidence of cGVHD decreases. However, the optimal dose and timing of ATG remain… read more here.
Keywords: thymocyte globulin; atg; globulin atg; anti thymocyte ... See more keywords
Comparison of two dosages of rabbit antithymocyte globulin (r-ATG) in treating children with severe aplastic anemia.
Sign Up to like & getrecommendations! Published in 2018 at "Die Pharmazie"
DOI: 10.1691/ph.2018.7353
Abstract: In this study, efficacy and safety of two different dosages of rabbit antithymocyte globulin (r-ATG) combined with cyclosporine (CsA) in treating children with severe aplastic anemia (SAA) were compared. The clinical data of 122 SAA… read more here.
Keywords: globulin atg; atg; dosages rabbit; rabbit antithymocyte ... See more keywords
Meta-analysis of the actions of antithymocyte globulin in patients undergoing allogeneic hematopoietic cell transplantation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.14719
Abstract: Graft-versus-host disease (GVHD) is a serious complication associated with allogeneic hematopoietic cell transplantation (allo-HCT). Antithymocyte globulin (ATG) is widely used prior to allo-HCT for GVHD prevention, though evidence of its efficacy remains unclear. We therefore… read more here.
Keywords: atg; cell transplantation; allogeneic hematopoietic; hematopoietic cell ... See more keywords
Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes
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DOI: 10.2337/dc18-0494
Abstract: OBJECTIVE A pilot study suggested that combination therapy with low-dose anti-thymocyte globulin (ATG) and pegylated granulocyte colony-stimulating factor (GCSF) preserves C-peptide in established type 1 diabetes (T1D) (duration 4 months to 2 years). We hypothesized… read more here.
Keywords: low dose; dose atg; dose anti; atg ... See more keywords