DNTT activation, TdT‐aided gene length mutation, and better prognosis in ATG‐based regimen allo‐HSCT in AML
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DOI: 10.1002/mc.23514
Abstract: This study aimed to investigate the relationship between anomalous DNA nucleotidylexotransferase (DNTT) activation and the mutagenesis of gene length mutations (LMs) in acute myeloid leukemia (AML), and the relevance of their prognosis in antithymocyte globulin… read more here.
Keywords: regimen allo; aml; dntt activation; based regimen ... See more keywords
Clinical outcomes of frontline ATG-based immunosuppressive therapy in older patients with aplastic anemia
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DOI: 10.1182/blood-2025-3206
Abstract: Aplastic anemia (AA) exhibits a bimodal age distribution with incidence peaks in young adults and patients aged >60 years. Despite advances in AA management, including the addition of eltrombopag to ATG-cyclosporine and expanded transplant options,… read more here.
Keywords: age; atg based; therapy; response ... See more keywords
Comparison of alemtuzumab and ATG-based conditioning in adult recipients of allogeneic hematopoietic cell transplantation (HCT) for severe aplastic anemia: A retrospective study
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DOI: 10.1182/blood-2025-4207
Abstract: Background The optimal in-vivo T-cell depleting agent for allogeneic hematopoietic cell transplantation (HCT) for patients with severe aplastic anemia (SAA) remains unclear. Current guidelines endorse the use of either rabbit anti-thymocyte globulin (ATG) or alemtuzumab,… read more here.
Keywords: alemtuzumab atg; atg based; hct; cell ... See more keywords
Low-dose post-transplant cyclophosphamide with G-CSF/ATG based haploidentical protocol provides favorable outcomes for SAA patients
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DOI: 10.3389/fimmu.2023.1173320
Abstract: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT), as one of the life-saving treatments for severe aplastic anemia (SAA), is widely used because of its great donor availability. Over decades, granulocyte colony-stimulating factor (G-CSF)/antithymocyte globulin (ATG)-based protocol… read more here.
Keywords: post transplant; dose post; atg based; post ... See more keywords