Phase separation organizes the site of autophagosome formation
Sign Up to like & getrecommendations! Published in 2020 at "Nature"
DOI: 10.1038/s41586-020-1977-6
Abstract: Many biomolecules undergo liquid–liquid phase separation to form liquid-like condensates that mediate diverse cellular functions 1 , 2 . Autophagy is able to degrade such condensates using autophagosomes—double-membrane structures that are synthesized de novo at… read more here.
Keywords: phase separation; formation; separation; atg proteins ... See more keywords
EIF5A mediates autophagy via translation of ATG3
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DOI: 10.1080/15548627.2018.1491213
Abstract: ABSTRACT The core macroautophagy/autophagy machinery consists of a large group of autophagy-related (ATG) proteins, that mediate highly controlled, step-wise execution of this conserved intracellular degradation process. Whereas ATG proteins have been intensely studied in terms… read more here.
Keywords: eif5a; eif5a mediates; atg3; translation ... See more keywords
High-throughput screening of functional deubiquitinating enzymes in autophagy
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DOI: 10.1080/15548627.2020.1761652
Abstract: ABSTRACT Macroautophagy/autophagy, a eukaryotic homeostatic process that sequesters cytoplasmic constituents for lysosomal degradation, is orchestrated by a number of autophagy-related (ATG) proteins tightly controlled by post-translational modifications. However, the involvement of reversible ubiquitination in the… read more here.
Keywords: throughput screening; autophagy; atg proteins; autophagy high ... See more keywords