ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction
Sign Up to like & getrecommendations! Published in 2018 at "Autophagy"
DOI: 10.1080/15548627.2017.1422851
Abstract: ABSTRACT ULK1 (unc51-like autophagy activating kinase 1) is a serine/threonine kinase that plays a key role in regulating macroautophagy/autophagy induction in response to amino acid starvation. Despite the recent progress in understanding ULK1 functions, the… read more here.
Keywords: autophagy induction; ulk1 phosphorylates; autophagy; atg14 ... See more keywords
Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages.
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1909833
Abstract: Dysfunction of macroautophagy/autophagy in macrophages contributes to atherosclerosis. Impaired autophagy-lysosomal degradation system leads to lipid accumulation, facilitating atherosclerotic plaque. ATG14 is an essential regulator for the fusion of autophagosomes with lysosomes. Whether ATG14 plays a… read more here.
Keywords: lysosome fusion; inflammation; autophagosome lysosome; augmenting atg14 ... See more keywords