Metformin attenuates lipopolysaccharide‐induced epithelial cell senescence by activating autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biology International"
DOI: 10.1002/cbin.11536
Abstract: Acute lung injury (ALI) is a life‐threatening medical condition with higher mortality and morbidity in elderly patients. Recently, metformin, a drug commonly used to lower blood glucose in type 2 diabetes patients, has been shown… read more here.
Keywords: epithelial cell; cell senescence; atg5; senescence ... See more keywords
Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.11.018
Abstract: Autophagy and autophagy-related genes (Atg) have been attributed prominent roles in tumorigenesis, tumor growth, and metastasis. Extracellular vesicles called exosomes are also implicated in cancer metastasis. Here, we demonstrate that exosome production is strongly reduced… read more here.
Keywords: v1v0 atpase; atg5; metastasis; exosome production ... See more keywords
Protocatechuic Aldehyde Alleviates d-Galactose–Induced Cardiomyocyte Senescence by Regulating the TCF3/ATG5 Axis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001394
Abstract: Abstract: Cardiomyocyte senescence is an independent risk factor for cardiovascular diseases. Protocatechuic aldehyde (PCA) is a natural chemical in the Chinese medicinal herb Salvia miltiorrhiza. PCA could protect against oxidative stress and inflammation in the… read more here.
Keywords: inflammation; atg5; galactose induced; cardiomyocyte senescence ... See more keywords
MiR-30a-5p promotes vein graft restenosis by inhibiting cell autophagy through targeting ATG5.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220801162756
Abstract: OBJECTIVE To investigate the role of miR-30a-5p in restenosis of rats following vein grafting and the underlying mechanism. METHODS Vein graft rat models were established and perfused with miR-30a-5p antagomir and si-ATG5 to probe the… read more here.
Keywords: graft restenosis; atg5; restenosis; mir 30a ... See more keywords
A Feedback Loop between TGF-β1 and ATG5 Mediated by miR-122-5p Regulates Fibrosis and EMT in Human Trabecular Meshwork Cells
Sign Up to like & getrecommendations! Published in 2023 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb45030154
Abstract: Autophagy is a cell’s evolutionary conserved process for degrading and recycling cellular proteins and removing damaged organelles. There has been an increasing interest in identifying the basic cellular mechanism of autophagy and its implications in… read more here.
Keywords: atg5; mir 122; trabecular meshwork; tgf ... See more keywords
Deubiquitinase USP13 regulates glycolytic reprogramming and progression in osteosarcoma by stabilizing METTL3/m6A/ATG5 axis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.82081
Abstract: Reprogramming metabolism is a hallmark of cancer cells for rapid progression. However, the detailed functional role of deubiquitinating enzymes (DUBs) in tumor glycolytic reprogramming is still unknown and requires further investigation. USP13 was found to… read more here.
Keywords: stabilizing mettl3; atg5; progression; mettl3 ... See more keywords