Targeting the ATG5-ATG16L1 Protein-Protein Interaction with a Hydrocarbon-Stapled Peptide Derived from ATG16L1 for Autophagy Inhibition.
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DOI: 10.1021/jacs.2c07648
Abstract: Selective modulation of autophagy is a promising therapeutic strategy, especially for cancer treatment. However, the lack of specific autophagy inhibitors limits this strategy. The formation of the ATG12-ATG5-ATG16L1 complex is essential for targeting the ATG12-ATG5… read more here.
Keywords: atg5 atg16l1; protein protein; targeting atg5; atg16l1 protein ... See more keywords