Autophagy-related gene ATG7 participates in the asexual development, stress response and virulence of filamentous insect pathogenic fungus Beauveria bassiana
Sign Up to like & getrecommendations! Published in 2019 at "Current Genetics"
DOI: 10.1007/s00294-019-00955-1
Abstract: Autophagy is a sophisticated mechanism for maintaining cellular homeostasis, in which E1-like enzyme (ATG7) controls the activation of ubiquitin-like conjugation system in the autophagy pathway. In the insect pathogenic fungus Beauveria bassiana, a yeast ortholog… read more here.
Keywords: atg7; insect pathogenic; virulence; stress ... See more keywords
circPAN3 exerts a profibrotic role via sponging miR-221 through FoxO3/ATG7-activated autophagy in a rat model of myocardial infarction.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118015
Abstract: BACKGROUND Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3… read more here.
Keywords: atg7; mir 221; cardiac fibrosis; model ... See more keywords
A cancer associated somatic mutation in LC3B attenuates its binding to E1-like ATG7 protein and subsequent lipidation
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2018.1525476
Abstract: ABSTRACT Macroautophagy/autophagy is a conserved catabolic process that maintains cellular homeostasis under basal growth and stress conditions. In cancer, autophagy can either prevent or promote tumor growth, at early or advanced stages, respectively. We screened… read more here.
Keywords: protein; atg7; lipidation; cancer ... See more keywords
Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1635379
Abstract: ABSTRACT A shared neuropathological hallmark in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is nuclear clearance and cytoplasmic aggregation of TARDBP/TDP-43 (TAR DNA binding protein). We previously showed that the ability of TARDBP to… read more here.
Keywords: tardbp tdp; atg7; tardbp; motor ... See more keywords
Ablation of endothelial Atg7 inhibits ischemia-induced angiogenesis by upregulating Stat1 that suppresses Hif1a expression
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2139920
Abstract: ABSTRACT Ischemia-induced angiogenesis is critical for blood flow restoration and tissue regeneration, but the underlying molecular mechanism is not fully understood. ATG7 (autophagy related 7) is essential for classical degradative macroautophagy/autophagy and cell cycle regulation.… read more here.
Keywords: atg7; expression; hif1a expression; factor ... See more keywords
Autophagy protein Atg7 is essential for maintaining malaria parasite cellular homeostasis and organelle biogenesis
Sign Up to like & getrecommendations! Published in 2024 at "mBio"
DOI: 10.1128/mbio.02735-24
Abstract: ABSTRACT Plasmodium parasites have a complex life cycle that transitions between mosquito and mammalian hosts, and undergo continuous cellular remodeling to adapt to various drastic environments. Following hepatocyte invasion, the parasite discards superfluous organelles for… read more here.
Keywords: organelle biogenesis; atg7; plasmodium; parasite ... See more keywords
Circ_0058051 Targeted miR-129-5P Regulates Autophagy-Related Gene ATG7 to Promote the Inflammation of Gout
Sign Up to like & getrecommendations! Published in 2025 at "Mediators of Inflammation"
DOI: 10.1155/mi/6645479
Abstract: Gout is a common autoinflammatory disease that clinically manifests as recurrent joint redness, swelling, and pain, but the molecular mechanism of recurrent gouty inflammation remains unclear. Circular RNAs (circRNAs) might exert their function by regulating… read more here.
Keywords: gout; mir 129; circ 0058051; atg7 ... See more keywords
Abstract 4383: CD44s is a crucial ATG7 downstream regulator for formation of sphere, a key stem-like property, invasion and lung metastasis of human bladder cancer/BC cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4383
Abstract: Over half a million US residents are suffering with bladder cancer (BC), which costs a total $4 billion in treatment annually. Although recent studies report that autophagy-related gene 7 (ATG7) is overexpressed in BCs, the… read more here.
Keywords: atg7; cd44s; invasion; formation ... See more keywords
Abstract We123: Cardiomyocyte Specific Sustained Atg7 Overexpression Activates Mitochondrial Autophagy in the Heart
Sign Up to like & getrecommendations! Published in 2024 at "Circulation Research"
DOI: 10.1161/res.135.suppl_1.we123
Abstract: Introduction: Accumulating evidence indicates that autophagy-related protein 7 (Atg7) is essential in cellular autophagy. Our earlier studies showed that Atg7 is required to promote macro-autophagy in the heart. However, it is unknown if the activation… read more here.
Keywords: mice; heart; atg7; activation ... See more keywords
A Functional Variant rs2122031 in ATG7 Is Associated with the Risk of Radiation Pneumonitis
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DOI: 10.1165/rcmb.2024-0238oc
Abstract: Radiation pneumonitis (RP) is characterized by inflammation and is associated with autophagy. However, the relationship between functional genetic variants of autophagy-related genes and RP remains unknown. In this study, we aimed to investigate whether genetic… read more here.
Keywords: atg7 associated; radiation; atg7; radiation pneumonitis ... See more keywords
Effect of miR-202-5p-mediated ATG7 on autophagy and apoptosis of degenerative nucleus pulposus cells.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202001_20027
Abstract: OBJECTIVE This study aimed to research the effect of miR-202-5p-mediated ATG7 on autophagy and apoptosis of degenerative nucleus pulposus cells. PATIENTS AND METHODS The intervertebral disc nucleus pulposus (NP) tissue of patients with intervertebral disc… read more here.
Keywords: atg7; apoptosis; expression; nucleus pulposus ... See more keywords