Altered distribution of ATG9A and accumulation of axonal aggregates in neurons from a mouse model of AP-4 deficiency syndrome
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007363
Abstract: The hereditary spastic paraplegias (HSP) are a clinically and genetically heterogeneous group of disorders characterized by progressive lower limb spasticity. Mutations in subunits of the heterotetrameric (ε-β4-μ4-σ4) adaptor protein 4 (AP-4) complex cause an autosomal… read more here.
Keywords: model deficiency; deficiency syndrome; limb spasticity; deficiency ... See more keywords
Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.2139/ssrn.4009227
Abstract: ATG9A is a highly conserved membrane protein required for autophagy initiation. It is trafficked from the trans-Golgi network (TGN) to the phagophore to act as a membrane source for autophagosome expansion. Here, we show that… read more here.
Keywords: nondegradable ubiquitinated; atg9a organizes; ubiquitinated atg9a; atg9a ... See more keywords