Anti‐Atherosclerotic Effects of Vitamins D and E in Suppression of Atherogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25738
Abstract: Atherosclerosis is a progressive and multifactorial disease which occurs under the influence of various risk factors including endothelial dysfunction (ED), oxidative stress, and low‐density lipoprotein (LDL) oxidation. In contract to the initial hypotheses on the… read more here.
Keywords: vitamins suppression; atherosclerotic effects; effects vitamins; anti atherosclerotic ... See more keywords
Unlike estrogens that increase PCSK9 levels post-menopause HSP27 vaccination lowers cholesterol levels and atherogenesis due to divergent effects on PCSK9 and LDLR.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105222
Abstract: AIMS The estrogen-inducible protein Heat Shock Protein 27 (HSP27) as well as anti-HSP27 antibodies are elevated in healthy subjects compared to cardiovascular disease patients. Vaccination of ApoE-/- mice with recombinant HSP25 (rHSP25, the murine ortholog),… read more here.
Keywords: cholesterol levels; hsp27; pcsk9; post ... See more keywords
LDL and foam cell formation as the basis of atherogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Lipidology"
DOI: 10.1097/mol.0000000000000525
Abstract: Purpose of review Lipoprotein-induced intracellular lipid accumulation (foam cell formation) is a trigger of atherogenesis at the subendothelial arterial cell level. The purpose of this review is to describe the recent data related to the… read more here.
Keywords: foam cell; atherogenesis; cell formation; formation ... See more keywords
Resilience of the Internal Mammary Artery to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.316256
Abstract: Fueled by the global surge in aging, atherosclerotic cardiovascular disease reached pandemic dimensions putting affected individuals at enhanced risk of myocardial infarction, stroke, and premature death. Atherosclerosis is a systemic disease driven by a wide… read more here.
Keywords: atherogenesis; artery; mammary artery; risk ... See more keywords
Platelets and von Willebrand factor in atherogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-07-692673
Abstract: The role of platelet adhesion, activation, and aggregation in acute atherothrombotic events such as myocardial infarction and stroke is well established. There is increasing evidence that platelet-endothelial interactions also contribute to early atherosclerotic plaque initiation… read more here.
Keywords: platelets von; von willebrand; willebrand factor; factor ... See more keywords
Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0231582
Abstract: Atherosclerosis, the predominant cause of death in well-resourced countries, may develop in the presence of plasma lipid levels within the normal range. Inflammation may contribute to lesion development in these individuals, but the underlying mechanisms… read more here.
Keywords: plasma; def; plasma cholesterol; mice ... See more keywords
The Endothelium as a Hub for Cellular Communication in Atherogenesis: Is There Directionality to the Message?
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.888390
Abstract: Endothelial cells line every blood vessel and thereby serve as an interface between the blood and the vessel wall. They have critical functions for maintaining homeostasis and orchestrating vascular pathogenesis. Atherosclerosis is a chronic disease… read more here.
Keywords: communication; endothelial cells; endothelium hub; atherogenesis ... See more keywords
Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.675724
Abstract: We previously reported that histone deacetylase 6 (HDAC6) has an important role in endothelial cell (EC) function in vitro. However, whether HDAC6 plays a role in atherogenesis in vivo and the mechanism(s) that control HDAC6… read more here.
Keywords: hdac6 activity; neddylation; role; hdac6 ... See more keywords
The Importance of the Plasma Membrane in Atherogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Membranes"
DOI: 10.3390/membranes12111036
Abstract: Atherosclerotic cardiovascular diseases are an important medical problem due to their high prevalence, impact on quality of life and prognosis. The pathogenesis of atherosclerosis is an urgent medical and social problem, the solution of which… read more here.
Keywords: importance plasma; quality; membrane atherogenesis; atherogenesis ... See more keywords
Natural cocoa inhibits maternal hypercholesterolaemia-induced atherogenesis in rabbit pups.
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular journal of Africa"
DOI: 10.5830/cvja-2019-019
Abstract: Atherosclerosis begins during foetal development and is enhanced by maternal hypercholesterolaemia during pregnancy. This study assessed the effect of natural cocoa on atherosclerosis in offspring conceived in maternal hypercholesterolaemia. Female rabbits were fed a cholesterol-enriched… read more here.
Keywords: atherogenesis; maternal hypercholesterolaemia; natural cocoa; hypercholesterolaemia ... See more keywords