Carotid Atherosclerosis, Microalbuminuria, and Estimated 10-Year Atherosclerotic Cardiovascular Disease Risk in Sub-Saharan Africa.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2022.7559
Abstract: Importance Carotid atherosclerosis and microalbuminuria are associated with atherosclerotic cardiovascular disease (ASCVD) but are understudied in sub-Saharan Africa. Objective To evaluate the association of carotid atherosclerosis and microalbuminuria with 10-year ASCVD risk in middle-aged sub-Saharan… read more here.
Keywords: atherosclerosis; carotid atherosclerosis; risk; year ... See more keywords
A Zombie Macrophage‐Based “Trojan horse” Enhances the Effect of Efferocytosis Through Immune Regulation for Atherosclerosis Treatment
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202315034
Abstract: Various immune cell‐mediated drug delivery systems have been reported for precision medicine, but the proinflammatory differentiation of immunocyte vehicles can exacerbate disease progression, resulting in a formidable obstacle to efficacious pharmacotherapy. The progression of atherosclerosis… read more here.
Keywords: treatment; atherosclerosis; macrophage; trojan horse ... See more keywords
Interface Allocation Precisely Customized Janus Upconversion Nanomotor for Atherosclerosis Amelioration
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202405916
Abstract: Spatial and temporal precisely control of direction and speed is crucial for nanomotors to enable complex operations and applications in microsurgery, drug delivery, isolation of biological targets, and so on. Judicious material design involving Janus… read more here.
Keywords: janus upconversion; janus; atherosclerosis; interface allocation ... See more keywords
Duplex Responsive Nanoplatform with Cascade Targeting for Atherosclerosis Photoacoustic Diagnosis and Multichannel Combination Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials"
DOI: 10.1002/adma.202300439
Abstract: The culprits of atherosclerosis are endothelial damage, local disorders of lipid metabolism, and progressive inflammation. Early atherosclerosis is typically difficult to diagnose in time due to the lack of obvious symptoms, thus missing the best… read more here.
Keywords: pmetpp mbt; duplex responsive; photoacoustic diagnosis; atherosclerosis ... See more keywords
Plaque‐Targeted Rapamycin Spherical Nucleic Acids for Synergistic Atherosclerosis Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202105875
Abstract: Atherosclerosis with unstable plaques is the dominant pathological basis of lethal cardio‐cerebrovascular diseases, which can cause acute death due to the rupture of plaques. Plaque‐targeted drug delivery to achieve promoted treatment remains the main challenge… read more here.
Keywords: atherosclerosis treatment; treatment; atherosclerosis; rap sna ... See more keywords
Dipeptidyl Peptidase 4/Midline‐1 Axis Promotes T Lymphocyte Motility in Atherosclerosis
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DOI: 10.1002/advs.202204194
Abstract: T cells play a crucial role in atherosclerosis, with its infiltration preceding the formation of atheroma. However, how T‐cell infiltration is regulated in atherosclerosis remains largely unknown. Here, this work demonstrates that dipeptidyl peptidase‐4 (DPP4)… read more here.
Keywords: dipeptidyl peptidase; dpp4; motility; atherosclerosis ... See more keywords
Decursin‐Loaded Nanovesicles Target Macrophages Driven by the Pathological Process of Atherosclerosis
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DOI: 10.1002/advs.202417489
Abstract: Atherosclerosis (AS) is a major pathological factor contributing to the mortality associated with ischemic heart disease and is driven primarily by macrophage‐mediated lipid accumulation and inflammatory processes. Conventional cardiovascular pharmacotherapies address these pathological mechanisms but… read more here.
Keywords: decursin loaded; lipid accumulation; atherosclerosis; target ... See more keywords
The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress
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DOI: 10.1002/advs.202501981
Abstract: Disturbed blood flow and the resulting oscillatory low shear stress (OSS) are key contributors to vascular endothelial dysfunction and the initiation of atherosclerosis. However, the molecular mediators that translate abnormal hemodynamic signals into pathological vascular… read more here.
Keywords: vascular endothelial; grk2; atherosclerosis; endothelial dysfunction ... See more keywords
Nanoparticle Drug Delivery Systems for Atherosclerosis: Precision Targeting, Inflammatory Modulation, and Plaque Stabilization
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202504990
Abstract: Atherosclerosis remains a leading contributor to cardiovascular morbidity and mortality, presenting considerable therapeutic challenges due to its multifaceted and complex pathogenesis. This review systematically explores the pathophysiological mechanisms underlying atherosclerosis and examines recent advances in… read more here.
Keywords: drug delivery; atherosclerosis; delivery systems; drug ... See more keywords
Leucine-Dependent SLC7A5-PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202518359
Abstract: The residual risks of advanced atherosclerosis remain substantial despite current preventive strategies and pharmacotherapy. Circulating branched-chain amino acids are biomarkers of cardiovascular disease risk. However, the mechanism of leucine in atherosclerosis progression remains unclear. Leucine… read more here.
Keywords: mitochondrial function; pgam5; function; atherosclerosis ... See more keywords
Association between atherosclerosis and Alzheimer's disease: A systematic review and meta‐analysis
Sign Up to like & getrecommendations! Published in 2020 at "Brain and Behavior"
DOI: 10.1002/brb3.1601
Abstract: To evaluate the relationship between atherosclerosis and Alzheimer's disease (AD), we conducted a systematic review and meta‐analysis to study the difference of carotid intima–media thickness (CIMT) and the prevalence of atherosclerosis between AD patients and… read more here.
Keywords: review meta; alzheimer disease; systematic review; atherosclerosis alzheimer ... See more keywords