Effects of 17β-estradiol and equilin on atherosclerosis development in female Apoeshl mice
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DOI: 10.1038/s41598-025-10494-0
Abstract: The effects of conjugated equine estrogens (CEE) and 17β-estradiol-based hormone replacement therapy (HRT) on atherosclerosis development remain controversial. Here, we investigated the effects of equilin, a major compound in CEE, and 17β-estradiol on atherosclerosis development… read more here.
Keywords: apoeshl mice; atherosclerosis; estradiol equilin; atherosclerosis development ... See more keywords
Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidaemia and atherosclerosis development in APOE*3-Leiden.CETP mice
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DOI: 10.1093/cvr/cvae195
Abstract: Abstract Aims Angiopoietin-like 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase to regulate tissue fatty acid (FA) uptake from triglyceride (TG)-rich lipoproteins such as very low density lipoproteins (VLDL). While pharmacological inhibition of ANGPTL3 is… read more here.
Keywords: liver targeted; angptl4 silencing; atherosclerosis development; targeted angptl4 ... See more keywords
Colesevelam enhances the beneficial effects of brown fat activation on hyperlipidaemia and atherosclerosis development
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DOI: 10.1093/cvr/cvz253
Abstract: Abstract Aims Brown fat activation accelerates the uptake of cholesterol-enriched remnants by the liver and thereby lowers plasma cholesterol, consequently protecting against atherosclerosis development. Hepatic cholesterol is then converted into bile acids (BAs) that are… read more here.
Keywords: atherosclerosis development; fat activation; cholesterol; brown fat ... See more keywords
Macrophages Promote Atherosclerosis Development by Inhibiting CD8T Cell Apoptosis
Sign Up to like & getrecommendations! Published in 2024 at "Mediators of Inflammation"
DOI: 10.1155/2024/1929766
Abstract: Background Atherosclerosis is an inflammatory cardiovascular disease. However, whether the association of immune cells in plaques promotes the progression of this disease has not yet been completely elucidated. Materials and Methods Thus, this study aimed… read more here.
Keywords: atherosclerosis development; atherosclerosis; promote atherosclerosis; cd8t cell ... See more keywords
Aortic Gene Expression Profiles Show How ApoA-I Levels Modulate Inflammation, Lysosomal Activity, and Sphingolipid Metabolism in Murine Atherosclerosis
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DOI: 10.1161/atvbaha.120.315669
Abstract: Supplemental Digital Content is available in the text. Objective: HDL (high-density lipoprotein) particles are known to possess several antiatherogenic properties that include the removal of excess cholesterol from peripheral tissues, the maintenance of endothelial integrity,… read more here.
Keywords: gene expression; mice; atherosclerosis development; eko mice ... See more keywords
The human milk oligosaccharide 3′sialyllactose reduces low-grade inflammation and atherosclerosis development in mice
Sign Up to like & getrecommendations! Published in 2024 at "JCI Insight"
DOI: 10.1172/jci.insight.181329
Abstract: Macrophages contribute to the induction and resolution of inflammation and play a central role in chronic low-grade inflammation in cardiovascular diseases caused by atherosclerosis. Human milk oligosaccharides (HMOs) are complex unconjugated glycans unique to human… read more here.
Keywords: atherosclerosis development; atherosclerosis; grade inflammation; human milk ... See more keywords
The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy
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DOI: 10.3390/biomedicines10020254
Abstract: Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS (endothelial nitric oxide synthase) expression, subsequent NO (nitric oxide)… read more here.
Keywords: role klf2; atherosclerosis development; klf2; atherosclerosis ... See more keywords
Functional Phenotypes of Intraplaque Macrophages and Their Distinct Roles in Atherosclerosis Development and Atheroinflammation
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020452
Abstract: Macrophages are the key inflammatory cell type involved in all stages of atherosclerosis development and progression, as demonstrated by numerous studies. Correspondingly, macrophages are currently regarded as a promising therapeutic target for the development of… read more here.
Keywords: development; phenotypes intraplaque; macrophages distinct; intraplaque macrophages ... See more keywords
Unraveling the Transcriptional Dynamics of NASH Pathogenesis Affecting Atherosclerosis
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DOI: 10.3390/ijms23158229
Abstract: The prevalence of non-alcoholic steatohepatitis (NASH) is rapidly increasing and associated with cardiovascular disease (CVD), the major cause of mortality in NASH patients. Although sharing common risk factors, the mechanisms by which NASH may directly… read more here.
Keywords: unraveling transcriptional; dynamics nash; development; atherosclerosis development ... See more keywords
SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.74864
Abstract: Steroid receptor coactivator 3 (SRC-3) is a member of the p160 SRC family. This factor can interact with multiple nuclear hormone receptors and transcription factors to regulate the expression of their target genes. Although many… read more here.
Keywords: macrophage recruitment; atherosclerosis development; expression; src ... See more keywords