Intermittent high-fat diet: atherosclerosis progression by neutrophil reprogramming
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-02027-4
Abstract: A recent study published in Nature by Lavillegrand et al. provided insights into how alternating high-fat diet (HFD) feeding reprograms neutrophil production and consequently promotes atheroprogression. 1 These fi ndings have translational implications, offering insights… read more here.
Keywords: intermittent high; fat diet; atherosclerosis progression; diet atherosclerosis ... See more keywords
N-Acetylneuraminic acid triggers endothelial pyroptosis and promotes atherosclerosis progression via GLS2-mediated glutaminolysis pathway
Sign Up to like & getrecommendations! Published in 2024 at "Cell Death Discovery"
DOI: 10.1038/s41420-024-02233-7
Abstract: Vascular endothelial injury initiates atherosclerosis (AS) progression. N-Acetylneuraminic acid (Neu5Ac) metabolic disorder was found to intensify endothelial mitochondrial damage. And GLS2-associated glutaminolysis disorder contributed to mitochondrial dysfunction. However, mechanisms underlying Neu5Ac-associated mitochondrial dysfunction as well… read more here.
Keywords: pyroptosis; progression; glutaminolysis; gls2 ... See more keywords
Spatial transcriptomics elucidates localized immune responses in atherosclerotic coronary artery
Sign Up to like & getrecommendations! Published in 2025 at "EMBO Molecular Medicine"
DOI: 10.1038/s44321-025-00280-w
Abstract: Atherosclerosis is characterized by the accumulation of lipids and immune cells in the arterial wall, leading to the narrowing and stiffening of blood vessels. Innate and adaptive immunity are involved in the pathogenesis of human… read more here.
Keywords: spatial transcriptomics; progression; cell; atherosclerosis progression ... See more keywords
Myostatin mediates abdominal aortic atherosclerosis progression by inducing vascular smooth muscle cell dysfunction and monocyte recruitment
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep46362
Abstract: Myostatin (Mstn) is a skeletal muscle growth inhibitor involved in metabolic disorders and heart fibrosis. In this study we sought to verify whether Mstn is also operative in atherosclerosis of abdominal aorta. In human specimens,… read more here.
Keywords: mstn; muscle; smooth muscle; atherosclerosis progression ... See more keywords
Mitophagy: Critical Role in Atherosclerosis Progression.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2022.0249
Abstract: Autophagy maintains intracellular homeostasis in the cardiovascular system, including in cardiomyocytes, endothelial cells (ECs), and arterial smooth muscle cells. Mitophagy, a selective autophagy that specifically removes damaged and dysfunctional mitochondria, is particularly important for cardiovascular… read more here.
Keywords: mitophagy critical; atherosclerosis progression; role atherosclerosis; biology ... See more keywords
Abstract We0068: Cysteinyl Leukotriene Receptors Modulate Macrophage-Endothelial Cell Crosstalk and Atherosclerosis Progression
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.we0068
Abstract: Introduction: Atherosclerosis, a major cause of cardiovascular disease, develops when cholesterol-rich plaques build up in the arteries, causing narrowing of the artery lumen. Consequently, atherosclerosis is an inflammatory disease that involves endothelial cell (EC) and… read more here.
Keywords: endothelial cell; macrophage; atherosclerosis; atherosclerosis progression ... See more keywords
Abstract 4139421: Rates Of Atherosclerosis Progression In The Absence Of Cardiovascular Events And Cardiovascular Medications On Cardiac Computed Tomography.
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4139421
Abstract: Introduction: Rates of progression of atherosclerosis have been derived from populations with established atherosclerotic cardiovascular disease and on plaque modifying therapies. However, the rate of atherosclerosis progression in populations with no history of MACE, risk… read more here.
Keywords: pav; progression; plaque; absence ... See more keywords
Proteomic and histopathologic profiling reveal molecular features and clinical biomarkers of coronary atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Biomarker Research"
DOI: 10.1186/s40364-025-00846-3
Abstract: The molecular features of coronary atherosclerosis progression remain incompletely understood. A comprehensive characterization of coronary proteome dynamics during atherosclerosis progression could facilitate the identification of novel biomarkers for early detection of plaque initiation and risk… read more here.
Keywords: coronary atherosclerosis; atherosclerosis; atherosclerosis progression; molecular features ... See more keywords
Involvement of enhanced expression of classical complement C1q in atherosclerosis progression and plaque instability: C1q as an indicator of clinical outcome
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0262413
Abstract: Activation of the classical complement pathway plays a major role in regulating atherosclerosis progression, and it is believed to have both proatherogenic and atheroprotective effects. This study focused on C1q, the first protein in the… read more here.
Keywords: atherosclerosis progression; plaque instability; progression; c1q ... See more keywords
Long-term prognostic value of coronary atherosclerosis progression in patients with and without diabetes mellitus
Sign Up to like & getrecommendations! Published in 2025 at "Quantitative Imaging in Medicine and Surgery"
DOI: 10.21037/qims-2024-2961
Abstract: Background Studies of the long-term prognostic value of coronary atherosclerosis progression in patients with and without diabetes mellitus (DM) via serial coronary computed tomography angiography (CCTA) are limited. This study aimed to explore the long-term… read more here.
Keywords: coronary atherosclerosis; long term; progression; term prognostic ... See more keywords
Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE–/– Mice by Skewing Macrophages to the M2 Phenotype
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00464
Abstract: Atherosclerosis (AS) in diabetic patients is often associated with low stability, which might be largely attributed to unfavorable macrophage polarization and increased inflammatory response induced by hyperglycaemia. Ginsenoside Rg3 is one of the main active… read more here.
Keywords: stability; polarization; rg3; atherosclerosis progression ... See more keywords