Proteoglycan 4 regulates macrophage function without altering atherosclerotic lesion formation in a murine bone marrow-specific deletion model.
Sign Up to like & getrecommendations! Published in 2018 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2018.05.008
Abstract: BACKGROUND AND AIMS Proteoglycan 4 (Prg4) has a high structural similarity with the established atherosclerosis-modulating proteoglycan versican, but its role in atherogenesis is still unknown. Therefore, the impact of Prg4 deficiency on macrophage function in vitro… read more here.
Keywords: formation; atherosclerotic lesion; macrophage; prg4 ... See more keywords
Calcium deposition within coronary atherosclerotic lesion: Implications for plaque stability.
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DOI: 10.1016/j.atherosclerosis.2020.05.017
Abstract: Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion that shows calcification is pathologic intimal thickening in which calcifications appear as microcalcifications that vary in size from 15 μm to 1 mm in diameter), fragmented… read more here.
Keywords: fibrocalcific plaques; calcification; acute coronary; atherosclerotic lesion ... See more keywords
Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22819-3
Abstract: ShcA is an adaptor protein that binds to the cytoplasmic tail of receptor tyrosine kinases and of the Low Density Lipoprotein-related receptor 1 (LRP1), a trans-membrane receptor that protects against atherosclerosis. Here, we examined the… read more here.
Keywords: adhesion; shca; endothelial cells; atherosclerotic lesion ... See more keywords
Longitudinal In Vivo Monitoring of Atheroprogression in Hypercholesterolemic Mice Using Photoacoustic Imaging
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/a-2005-8784
Abstract: Background and Aim The ability to recognize and monitor atherosclerotic lesion development using noninvasive imaging is crucial in preventive cardiology. The aim of the present study was to establish a protocol for longitudinal monitoring of… read more here.
Keywords: vivo; atheroprogression; lesion; atherosclerotic lesion ... See more keywords
Efficacy of Terpenoid in Attenuating Aortic Atherosclerosis in Apolipoprotein-E Deficient Mice: A Meta-Analysis of Animal Studies
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DOI: 10.1155/2019/2931831
Abstract: Background The apolipoprotein E knockout (ApoE -/-) mouse model is well established for the study of terpenoids in the prevention of atherosclerosis. Studies investigating the clinical benefit of terpenoids in humans are scarce. This systematic… read more here.
Keywords: atherosclerotic lesion; mice; smd; atherosclerosis ... See more keywords
NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice—Brief Report
Sign Up to like & getrecommendations! Published in 2017 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.117.309575
Abstract: Objective— Inflammasomes are multiprotein complexes, and their activation has been associated with cardiovascular disease. Inflammasome activation leads to secretion of caspase-1 by innate immune cells, resulting in the activation of interleukin-1&bgr;. Recently, a potent and… read more here.
Keywords: mcc950; lesion development; atherosclerotic lesion; nlrp3 inflammasome ... See more keywords
Immune-Inflammatory Activation in Acute Coronary Syndromes: A Look into the Heart of Unstable Coronary Plaque
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DOI: 10.2174/1573403x12666161014093812
Abstract: In the last twenty years, our comprehension of the molecular mechanisms involved in the formation, progression and complication of atherosclerotic plaque has advanced significantly and the main role of inflammation and immunity in this phenomenon… read more here.
Keywords: acute coronary; coronary syndromes; blood; atherosclerotic lesion ... See more keywords
Atherosclerotic Lesion of the Carotid Artery in Indonesian Cynomolgus Monkeys Receiving a Locally Sourced Atherogenic Diet
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary Sciences"
DOI: 10.3390/vetsci9030105
Abstract: The atherosclerotic lesion is a principal hallmark of atherosclerotic animal models. This study aimed to assess lesions of the carotid artery in Indonesian cynomolgus monkeys exposed to an IPB-1 atherogenic diet. A total of 20… read more here.
Keywords: cynomolgus; atherogenic diet; cynomolgus monkeys; atherosclerotic lesion ... See more keywords