Driving T cells to human atherosclerotic plaques: CCL3/CCR5 and CX3CL1/CX3CR1 migration axes
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202049004
Abstract: The linkage of atherosclerosis to immune activation can be traced back as far as to Rudolf Virchow [1]. Cytokine release and alteration of surface marker expression on immune cells reflect this activation. Disorders characterized by… read more here.
Keywords: human atherosclerotic; atherosclerotic plaques; ccl3 ccr5; plaques ccl3 ... See more keywords
Perillaldehyde prevents the formations of atherosclerotic plaques through recoupling endothelial nitric oxide synthase
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27362
Abstract: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) is essential for cardiovascular homeostasis owing to its anti‐inflammatory, antithrombotic, antiproliferative, and antioxidant effects. Perillaldehyde (PAH), one of the major oil components in Perilla frutescens, has… read more here.
Keywords: synthase; atherosclerotic plaques; perillaldehyde prevents; formations atherosclerotic ... See more keywords
Recent Advances in Managing Atherosclerosis via Nanomedicine.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201702793
Abstract: Atherosclerosis, driven by chronic inflammation of the arteries and lipid accumulation on the blood vessel wall, underpins many cardiovascular diseases with high mortality rates globally, such as stroke and ischemic heart disease. Engineered bio-nanomaterials are… read more here.
Keywords: atherosclerotic plaques; managing atherosclerosis; recent advances; atherosclerosis ... See more keywords
Monitoring Cellularity and Expression of Key Markers in Atherosclerotic Plaques.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1924-7_30
Abstract: Atherosclerotic plaques are highly diverse and heterogeneous structures, even within the same individual, and can vary depending on its anatomical location within the vascular bed. Early in the disease and throughout its progression, immune cells… read more here.
Keywords: cellularity expression; key markers; expression key; atherosclerotic plaques ... See more keywords
Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4176-z
Abstract: Cardiovascular disease is the major cause of morbidity and mortality in developed countries and atherosclerosis is the major cause of cardiovascular disease. Atherosclerotic lesions obstruct blood flow in the arterial vessel wall and can rupture… read more here.
Keywords: atherosclerotic plaques; identification diagnosis; target identification; vessel wall ... See more keywords
Immunohistochemical Features of Different Types of Unstable Atherosclerotic Plaques of Coronary Arteries
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-018-4297-1
Abstract: We performed a complex morphological study of samples of different types of unstable atherosclerotic plaques obtained from 33 men with occlusive coronary atherosclerosis, who underwent coronary artery endarterectomy during coronary artery bypass surgery. In the… read more here.
Keywords: degenerative necrotic; inflammatory erosive; atherosclerotic plaques; different types ... See more keywords
Multiple Non-Essential Transition Metals Are Accumulated in Carotid Atherosclerotic Plaques: Missing Link in Atherosclerosis?
Sign Up to like & getrecommendations! Published in 2018 at "Biological Trace Element Research"
DOI: 10.1007/s12011-018-1481-0
Abstract: Population studies revealed that metal exposure through food, environment, and smoking was related with increased risk of cardiovascular disease. In this study, we determined complex chemical elements in surgical carotid endarterectomy specimens and carotid tissues… read more here.
Keywords: atherosclerotic plaques; essential transition; non essential; carotid endarterectomy ... See more keywords
Pet tracers for vulnerable plaque imaging
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Nuclear Medicine"
DOI: 10.1007/s12149-020-01458-7
Abstract: Most of the acute ischemic events, such as acute coronary syndromes and stroke, are attributed to vulnerable plaques. These lesions have common histological and pathophysiological features, including inflammatory cell infiltration, neo-angiogenesis, remodelling, haemorrhage predisposition, thin… read more here.
Keywords: pet tracers; pet; atherosclerotic plaques; vulnerable plaques ... See more keywords
Bacterial profile in human atherosclerotic plaques.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.06.016
Abstract: BACKGROUND AND AIMS Several studies have confirmed the presence of bacterial DNA in atherosclerotic plaques, but its contribution to plaque stability and vulnerability is unclear. In this study, we investigated whether the bacterial plaque-profile differed… read more here.
Keywords: bacterial dna; atherosclerotic plaques; dna; symptomatic patients ... See more keywords
Ex vivo culture of human atherosclerotic plaques: A model to study immune cells in atherogenesis.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.10.003
Abstract: BACKGROUND AND AIMS The mechanisms that drive atherosclerotic plaque progression and destabilization in humans remain largely unknown. Laboratory models are needed to study these mechanisms under controlled conditions. The aim of this study was to… read more here.
Keywords: human atherosclerotic; atherosclerotic plaques; study; model ... See more keywords
Two-photon excited fluorescence (TPEF) may be useful to identify macrophage subsets based on their metabolic activity and cellular responses in atherosclerotic plaques.
Sign Up to like & getrecommendations! Published in 2020 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2020.07.017
Abstract: BACKGROUND AND AIMS Atherosclerosis is characterized by the formation of lipid plaques within the arterial wall. In such plaques, the massive and continuous recruitment of circulating monocyte-derived macrophages induces inflammation, leading to plaque destabilization and… read more here.
Keywords: atherosclerotic plaques; cellular responses; metabolic activity; macrophage ... See more keywords