Whole body clonality analysis in an aggressive STLV-1 associated leukemia (ATLL) reveals an unexpected clonal complexity.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2016.12.022
Abstract: HTLV-1 causes Adult T cell Leukemia/Lymphoma (ATLL) in humans. We describe an ATL-like disease in a 9 year-old female baboon naturally infected with STLV-1 (the simian counterpart of HTLV-1), with a lymphocyte count over 1010/L,… read more here.
Keywords: clonal complexity; atll; clonality; stlv ... See more keywords
A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1
Sign Up to like & getrecommendations! Published in 2020 at "Modern Pathology"
DOI: 10.1038/s41379-020-0635-8
Abstract: Histopathological distinction between adult T-cell leukemia/lymphoma (ATLL) and other T-cell neoplasms is often challenging. The current gold standard for the accurate diagnosis of ATLL is the Southern blot hybridization (SBH) assay, which detects clonal integration… read more here.
Keywords: htlv; cell leukemia; atll; diagnostic algorithm ... See more keywords
Abstract 3965: A cytolytic effector CD8+ T cell response is associated with remission in adult T-cell leukemia/lymphoma
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DOI: 10.1158/1538-7445.am2024-3965
Abstract: Introduction: Adult T-cell leukemia/lymphoma (ATLL) is a rare blood cancer that develops in 3-5% of human T-lymphotropic virus-1 (HTLV1) carriers when the combination of viral oncoproteins and somatic mutations lead to malignant transformation of HTLV1… read more here.
Keywords: adult cell; cd8; response; atll ... See more keywords
Abstract 4498: Drug screens identify new therapeutic targets that synergize with EZH1/2 inhibition in adult T-cell leukemia/lymphoma
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DOI: 10.1158/1538-7445.am2025-4498
Abstract: Adult T-cell leukemia/lymphoma (ATLL), a rare form of non-Hodgkin lymphoma, affects approximately 2-5% of individuals infected by the retrovirus Human T-cell Lymphotropic Virus- 1 (HTLV-1). The disease has a dismal prognosis and resistance to chemotherapy… read more here.
Keywords: adult cell; drug; cell; atll ... See more keywords
Adult T-Cell Leukemia-Lymphoma Presenting Concurrently with Myelopathy
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DOI: 10.1159/000525174
Abstract: Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. Of the approximate ten to twenty million people currently infected worldwide, 4–9% of infected individuals develop adult T-cell leukemia/lymphoma (ATLL) or HTLV-associated myelopathy/tropical spastic… read more here.
Keywords: lymphoma; atll; adult cell; leukemia ... See more keywords
Mechanistic Analysis of Prolonged Negative Impacts of Anti-CCR4 Antibody Mogamulizumab on Regulatory T Cell Homeostasis after Allogeneic Hematopoietic Stem Cell Transplantation
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DOI: 10.1182/blood-2018-99-117548
Abstract: Adult T-cell leukemia/lymphoma (ATLL) is highly aggressive CD4+ T cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1). Normal cellular counterpart of ATLL is considered to be CD4+Foxp3+ regulatory T cells (Tregs) and… read more here.
Keywords: treg; ccr4; treatment; atll ... See more keywords
Epidemiology, Clinical Features, and Outcome of HTLV-1-Related Adult T-Cell Leukemia/Lymphoma in Latin America: A Study from the Latin American Group of Lymphoproliferative Disorders (GELL)
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DOI: 10.1182/blood-2020-140630
Abstract: INTRODUCTION: Adult T-cell leukemia/lymphoma (ATLL) is a mature peripheral T-cell neoplasm caused by the Human T-cell Leukemia Virus Type 1 (HTLV-1). HTLV-1 infects up to 10 million people worldwide and is most endemic in Southwestern… read more here.
Keywords: atll; epidemiology; speakers bureau; research funding ... See more keywords
Venetoclax Alone or in Combination Shows Promising Activity in Preclinical Models and Clinical Cases of Relapsed/Refractory North American Adult T-Cell Leukemia Lymphoma
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DOI: 10.1182/blood-2024-206160
Abstract: Background: North American ATLL (NA-ATLL) is a highly aggressive HTLV-I-associated T-cell malignancy with a dismal prognosis. Venetoclax has shown activity in other T-cell malignancies, alone or in combination with hypomethylating agents (HMA), AZT (Zidovudine) with… read more here.
Keywords: combination; atll cell; cell; atll ... See more keywords
Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions.
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DOI: 10.1182/blood.2019001815
Abstract: Adult T-cell leukemia/lymphoma (ATLL) in Japan presents at a median age of 70 and only 5% of patients are age read more here.
Keywords: landscape young; cd28 fusions; atll; genomic landscape ... See more keywords
Efficacy and manageable toxicity of mogamulizumab in a real-world North American cohort of adult T-cell leukemia/lymphoma (ATLL).
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DOI: 10.1200/jco.2025.43.16_suppl.e18603
Abstract: e18603 Background: Adult T-cell leukemia/lymphoma (ATLL), a malignancy of CD4+ T-cells linked to HTLV-1 infection, carries a poor prognosis. Treatment options beyond allogeneic transplantation remain limited. Mogamulizumab, a CCR4-targeting monoclonal antibody, is FDA-approved for relapsed… read more here.
Keywords: treatment; cohort; real world; atll ... See more keywords
The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis
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DOI: 10.1371/journal.pntd.0010807
Abstract: Background Adult T-cell leukemia/lymphoma (ATLL), a peripheral T-cell leukemia/lymphoma associated with the human T-cell lymphotropic virus type-1 (HTLV-1), has been classified following the clinical forms defined by Shimoyama in 1991. A suggestion to modify Shimoyama’s… read more here.
Keywords: cell; prognosis; atll; leukemia lymphoma ... See more keywords