Whole body clonality analysis in an aggressive STLV-1 associated leukemia (ATLL) reveals an unexpected clonal complexity.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2016.12.022
Abstract: HTLV-1 causes Adult T cell Leukemia/Lymphoma (ATLL) in humans. We describe an ATL-like disease in a 9 year-old female baboon naturally infected with STLV-1 (the simian counterpart of HTLV-1), with a lymphocyte count over 1010/L,… read more here.
Keywords: clonal complexity; atll; clonality; stlv ... See more keywords
A new diagnostic algorithm using biopsy specimens in adult T-cell leukemia/lymphoma: combination of RNA in situ hybridization and quantitative PCR for HTLV-1
Sign Up to like & getrecommendations! Published in 2020 at "Modern Pathology"
DOI: 10.1038/s41379-020-0635-8
Abstract: Histopathological distinction between adult T-cell leukemia/lymphoma (ATLL) and other T-cell neoplasms is often challenging. The current gold standard for the accurate diagnosis of ATLL is the Southern blot hybridization (SBH) assay, which detects clonal integration… read more here.
Keywords: htlv; cell leukemia; atll; diagnostic algorithm ... See more keywords
Adult T-Cell Leukemia-Lymphoma Presenting Concurrently with Myelopathy
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DOI: 10.1159/000525174
Abstract: Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus. Of the approximate ten to twenty million people currently infected worldwide, 4–9% of infected individuals develop adult T-cell leukemia/lymphoma (ATLL) or HTLV-associated myelopathy/tropical spastic… read more here.
Keywords: lymphoma; atll; adult cell; leukemia ... See more keywords
Mechanistic Analysis of Prolonged Negative Impacts of Anti-CCR4 Antibody Mogamulizumab on Regulatory T Cell Homeostasis after Allogeneic Hematopoietic Stem Cell Transplantation
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DOI: 10.1182/blood-2018-99-117548
Abstract: Adult T-cell leukemia/lymphoma (ATLL) is highly aggressive CD4+ T cell malignancy caused by human T-cell leukemia virus type 1 (HTLV-1). Normal cellular counterpart of ATLL is considered to be CD4+Foxp3+ regulatory T cells (Tregs) and… read more here.
Keywords: treg; ccr4; treatment; atll ... See more keywords
Epidemiology, Clinical Features, and Outcome of HTLV-1-Related Adult T-Cell Leukemia/Lymphoma in Latin America: A Study from the Latin American Group of Lymphoproliferative Disorders (GELL)
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DOI: 10.1182/blood-2020-140630
Abstract: INTRODUCTION: Adult T-cell leukemia/lymphoma (ATLL) is a mature peripheral T-cell neoplasm caused by the Human T-cell Leukemia Virus Type 1 (HTLV-1). HTLV-1 infects up to 10 million people worldwide and is most endemic in Southwestern… read more here.
Keywords: atll; epidemiology; speakers bureau; research funding ... See more keywords
Genomic landscape of young ATLL patients identifies frequent targetable CD28 fusions.
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DOI: 10.1182/blood.2019001815
Abstract: Adult T-cell leukemia/lymphoma (ATLL) in Japan presents at a median age of 70 and only 5% of patients are age read more here.
Keywords: landscape young; cd28 fusions; atll; genomic landscape ... See more keywords
The importance of the clinical classification of adult T-cell leukemia/lymphoma (ATLL) in the prognosis
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DOI: 10.1371/journal.pntd.0010807
Abstract: Background Adult T-cell leukemia/lymphoma (ATLL), a peripheral T-cell leukemia/lymphoma associated with the human T-cell lymphotropic virus type-1 (HTLV-1), has been classified following the clinical forms defined by Shimoyama in 1991. A suggestion to modify Shimoyama’s… read more here.
Keywords: cell; prognosis; atll; leukemia lymphoma ... See more keywords
Absence of FLT3 mutations in Iranian adult T-cell leukemia/lymphoma patients
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DOI: 10.14196/mjiri.32.47
Abstract: Background: Adult T cell leukemia lymphoma (ATLL) is a rare disease, significantly linked to the infection by the human T-cell lymphotropic virus 1(HTLV-1). ATLL is typically preceded by decades of clinical latency during which infected… read more here.
Keywords: cell leukemia; leukemia lymphoma; adult cell; atll ... See more keywords
Regulation of human T-cell leukemia virus type 1 antisense promoter by myocyte enhancer factor-2C in the context of adult T-cell leukemia and lymphoma
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DOI: 10.3324/haematol.2021.279542
Abstract: Adult T-cell leukemia and lymphoma (ATLL) is an intractable T-cell neoplasia caused by a retrovirus, namely human T-cell leukemia virus type 1 (HTLV-1). Patients suffering from ATLL present a poor prognosis and have a dearth… read more here.
Keywords: cell; antisense promoter; atll; cell leukemia ... See more keywords
A Preclinical Model for the ATLL Lymphoma Subtype With Insights Into the Role of Microenvironment in HTLV-1-Mediated Lymphomagenesis
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.01215
Abstract: Adult T cell Leukemia/Lymphoma (ATLL) is a mature T cell malignancy associated with Human T cell Leukemia Virus type 1 (HTLV-1) infection. Among its four main clinical subtypes, the prognosis of acute and lymphoma variants… read more here.
Keywords: lymphoma; microenvironment; atll; role ... See more keywords
Shikonin Induces ROS-Dependent Apoptosis Via Mitochondria Depolarization and ER Stress in Adult T Cell Leukemia/Lymphoma
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DOI: 10.3390/antiox12040864
Abstract: Adult T cell leukemia/lymphoma (ATLL) is an aggressive T-cell malignancy that develops in some elderly human T-cell leukemia virus (HTVL-1) carriers. ATLL has a poor prognosis despite conventional and targeted therapies, and a new safe… read more here.
Keywords: cell; stress; atll; apoptosis ... See more keywords