(Curcumin+sildenafil) enhances the efficacy of 5FU and anti‐PD1 therapies in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29580
Abstract: We have extended our analyses of (curcumin+sildenafil) biology. The drug combination caused vascularization and degradation of mutant K‐RAS that correlated with reduced phosphorylation of ERK1/2, AKT T308, mTORC1, mTORC2, ULK1 S757, STAT3, STAT5, and NFκB… read more here.
Keywords: ulk1 s317; drug; atm ampk; curcumin sildenafil ... See more keywords
Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy
Sign Up to like & getrecommendations! Published in 2018 at "Acta Pharmacologica Sinica"
DOI: 10.1038/s41401-018-0047-1
Abstract: Aescin, a natural mixture of triterpene saponins, has been reported to exert anticancer effect. Recent studies show that aescin increases intracellular reactive oxygen species (ROS) levels. However, whether the increased ROS play a role in… read more here.
Keywords: aescin; reactive oxygen; ampk ulk1; aescin induced ... See more keywords