Versatility of the Mec1ATM/ATR signaling network in mediating resistance to replication, genotoxic, and proteotoxic stresses
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DOI: 10.1007/s00294-018-0920-y
Abstract: The ataxia-telangiectasia mutated/ATM and Rad3-related (ATM/ATR) family proteins are evolutionarily conserved serine/threonine kinases best known for their roles in mediating the DNA damage response. Upon activation, ATM/ATR phosphorylate numerous targets to stabilize stalled replication forks,… read more here.
Keywords: protein; atr; versatility mec1atm; resistance ... See more keywords
Ovatodiolide isolated from Anisomeles indica induces cell cycle G2/M arrest and apoptosis via a ROS‐dependent ATM/ATR signaling pathways
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.09.050
Abstract: ABSTRACT Ovatodiolide was isolated from the traditional Chinese medicinal herb Anisomeles indica, possesses anti‐bacterial and anti‐inflammatory properties; however, the anti‐cancer activity and its mechanisms have been limitedly reported. This study aimed to examine the effect… read more here.
Keywords: dna damage; apoptosis; cell cycle; atm atr ... See more keywords
Structures and regulations of ATM and ATR, master kinases in genome integrity.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.12.010
Abstract: Homologous recombination (HR) is a faithful repair mechanism for double stranded DNA breaks. Two highly homologous master kinases, the tumour suppressors ATM and ATR (Tel1 and Mec1 in yeast), coordinate cell cycle progression with repair… read more here.
Keywords: master kinases; structures regulations; atr master; atm atr ... See more keywords
Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01884-x
Abstract: ATM and ATR are conserved regulators of the DNA damage response linked to cancer. Comprehensive DNA sequencing efforts identified ~4,000 cancer-associated mutations in ATM/ATR; however, their cancer implications remain largely unknown. To gain insights, we… read more here.
Keywords: functional genetic; cancer genome; cancer; atm atr ... See more keywords
Tumor acidosis-induced DNA damage response and tetraploidy enhance sensitivity to ATM and ATR inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "EMBO Reports"
DOI: 10.1038/s44319-024-00089-7
Abstract: Tumor acidosis is associated with increased invasiveness and drug resistance. Here, we take an unbiased approach to identify vulnerabilities of acid-exposed cancer cells by combining pH-dependent flow cytometry cell sorting from 3D colorectal tumor spheroids… read more here.
Keywords: atm atr; cancer cells; response; exposed cancer ... See more keywords
EBV encoded miRNA BART8-3p promotes radioresistance in nasopharyngeal carcinoma by regulating ATM/ATR signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20190415
Abstract: Resistance to radiotherapy is one of the main causes of treatment failure in patients with nasopharyngeal carcinoma (NPC). Epstein-Barr virus (EBV) infection is an important factor in the pathogenesis of NPC, and EBV-encoded microRNAs (miRNAs)… read more here.
Keywords: ebv encoded; atm atr; mir bart8; ebv mir ... See more keywords
Ataxia-televangelist mutated (ATM)/ ATR serine/threonine kinase (ATR)-mediated RAD51 recombinase (RAD51) promotes osteogenic differentiation and inhibits osteoclastogenesis in osteoporosis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2026729
Abstract: ABSTRACT Osteoporosis is a metabolic bone disease that significantly affects the quality of life and can even lead to death. In this study, we aimed to investigate the role of RAD51 recombinase (RAD51) in osteoblast… read more here.
Keywords: osteoporosis; rad51; osteogenic differentiation; atm atr ... See more keywords
Abstract 4519: ATM/ATR-SerRS pathway dominates hypoxic angiogenesis in tumor
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4519
Abstract: Hypoxia-induced angiogenesis is a critical response in multicellular organisms to maintain oxygen homeostasis. It is also an important mechanism to support tumor progression. Hypoxia activates hypoxia-inducible factor (HIF) and HIF-independent pathways to transcriptionally induce the… read more here.
Keywords: atr; hypoxia; atr serrs; trna synthetase ... See more keywords
Abstract 527: Atovaquone upregulates PD-L1 expression via activation of the ATM/ATR DNA damage response pathway
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-527
Abstract: Ovarian cancer is one of the deadliest gynecological malignancies, typically diagnosed at an advanced stage complicating standard treatments and shows a need for new treatment options. Previously our lab has shown that atovaquone, a known… read more here.
Keywords: dna damage; atm atr; cancer; atovaquone ... See more keywords
ATM and ATR Influence Meiotic Crossover Formation Through Antagonistic and Overlapping Functions in Caenorhabditis elegans
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DOI: 10.1534/genetics.119.302193
Abstract: During meiosis, formation of double-strand breaks (DSBs) and repair by homologous recombination between homologs creates crossovers (COs) that facilitate chromosome segregation. CO formation is tightly regulated to ensure the integrity of this process. The DNA… read more here.
Keywords: caenorhabditis elegans; formation; atm atr; repair ... See more keywords
Targeted Inhibition of DNA-PKcs, ATM, ATR, PARP, and Rad51 Modulate Response to X Rays and Protons
Sign Up to like & getrecommendations! Published in 2022 at "Radiation Research"
DOI: 10.1667/rade-22-00040.1
Abstract: Small molecule inhibitors are currently in preclinical and clinical development for the treatment of selected cancers, particularly those with existing genetic alterations in DNA repair and DNA damage response (DDR) pathways. Keen interest has also… read more here.
Keywords: atm atr; response; dna; dna pkcs ... See more keywords