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Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-18-1394
Abstract: AZD0156 is a potent and selective, bioavailable inhibitor of ataxia-telangiectasia mutated (ATM) protein, a signaling kinase involved in the DNA damage response. We present preclinical data demonstrating abrogation of irradiation-induced ATM signaling by low doses…
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Keywords:
pharmacology atm;
atm inhibitor;
inhibitor azd0156;
irradiation ... See more keywords
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Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-338
Abstract: Physical or chemical DNA damaging agents are among the most widely used classes of cancer therapeutics today. Radiotherapy and topoisomerase inhibitors induce double strand breaks (DSB) considered most dangerous if left unrepaired because they can…
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Keywords:
new investigational;
m3541;
atm inhibitor;
cancer ... See more keywords
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Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10111529
Abstract: Patients with advanced biliary tract cancer (BTC) inevitably experience progression after first-line, gemcitabine-based chemotherapy, due to chemo-resistance. The genetic alterations of DNA damage repair (DDR) genes are usually determined in BTC tumors. In this study,…
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Keywords:
atm inhibitor;
polymerase;
gemcitabine resistant;
btc ... See more keywords