Articles with "atm inhibitor" as a keyword



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Pharmacology of the ATM Inhibitor AZD0156: Potentiation of Irradiation and Olaparib Responses Preclinically

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Published in 2019 at "Molecular Cancer Therapeutics"

DOI: 10.1158/1535-7163.mct-18-1394

Abstract: AZD0156 is a potent and selective, bioavailable inhibitor of ataxia-telangiectasia mutated (ATM) protein, a signaling kinase involved in the DNA damage response. We present preclinical data demonstrating abrogation of irradiation-induced ATM signaling by low doses… read more here.

Keywords: pharmacology atm; atm inhibitor; inhibitor azd0156; irradiation ... See more keywords
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Abstract 338: A new investigational ATM Inhibitor, M3541, synergistically potentiates fractionated radiotherapy and chemotherapy in cancer cells and animal models

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Published in 2018 at "Cancer Research"

DOI: 10.1158/1538-7445.am2018-338

Abstract: Physical or chemical DNA damaging agents are among the most widely used classes of cancer therapeutics today. Radiotherapy and topoisomerase inhibitors induce double strand breaks (DSB) considered most dangerous if left unrepaired because they can… read more here.

Keywords: new investigational; m3541; atm inhibitor; cancer ... See more keywords
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ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner

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Published in 2020 at "Biomolecules"

DOI: 10.3390/biom10111529

Abstract: Patients with advanced biliary tract cancer (BTC) inevitably experience progression after first-line, gemcitabine-based chemotherapy, due to chemo-resistance. The genetic alterations of DNA damage repair (DDR) genes are usually determined in BTC tumors. In this study,… read more here.

Keywords: atm inhibitor; polymerase; gemcitabine resistant; btc ... See more keywords