Quantitative and Dynamic Imaging of ATM Kinase Activity.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6940-1_9
Abstract: Ataxia telangiectasia mutated (ATM) is a serine/threonine kinase critical to the cellular DNA-damage response, including DNA double-strand breaks (DSBs). ATM activation results in the initiation of a complex cascade of events facilitating DNA damage repair,… read more here.
Keywords: dna damage; kinase activity; kinase; atm kinase ... See more keywords
Functional Characterization of ATM Kinase Using Acetylation-Specific Antibodies.
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DOI: 10.1007/978-1-4939-6955-5_12
Abstract: The activation of ATM is critical in the DNA double strand breaks repair pathway. Acetylation of ATM by Tip60 histone acetyltransferase (HAT) plays a key role in the activation of ATM kinase activity in response… read more here.
Keywords: acetylation; acetylation specific; using acetylation; atm kinase ... See more keywords
Homeodomain Proteins Directly Regulate ATM Kinase Activity
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.06.089
Abstract: SUMMARY Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that coordinates the response to DNA double-strand breaks and oxidative stress. NKX3.1, a prostate-specific transcription factor, was recently shown to directly stimulate ATM kinase activity through its… read more here.
Keywords: kinase activity; kinase; homeodomain proteins; atm kinase ... See more keywords
Down‐regulation of NOX2 activity in phagocytes mediated by ATM‐kinase dependent phosphorylation
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.09.007
Abstract: Abstract NADPH oxidases (NOX) have many biological roles, but their regulation to control production of potentially toxic ROS molecules remains unclear. A previously identified insertion sequence of 21 residues (called NIS) influences NOX activity, and… read more here.
Keywords: nox2; activity; atm kinase; phosphorylation ... See more keywords
Design and Optimization of Novel Benzimidazole- and Imidazo[4,5-b]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02104
Abstract: The ATM kinase is a promising target in cancer treatment as an important regulator of the cellular response to DNA double-strand breaks. In this work, we present a new class of specific benzimidazole-based ATM inhibitors… read more here.
Keywords: optimization novel; atm kinase; kinase; based atm ... See more keywords
Small molecule inhibition of ATM kinase increases CRISPR-Cas9 1-bp insertion frequency
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DOI: 10.1038/s41467-021-25415-8
Abstract: Mutational outcomes following CRISPR-Cas9-nuclease cutting in mammalian cells have recently been shown to be predictable and, in certain cases, skewed toward single genotypes. However, the ability to control these outcomes remains limited, especially for 1-bp… read more here.
Keywords: molecule; frequency; insertion; small molecule ... See more keywords
FRI0396 The atm kinase and pten, drive myofibroblasts differentiation by activating the tgfΒ autocrine loop
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.5224
Abstract: Background Pulmonary fibrosis is a major cause of mortality in scleroderma (SSc) and Idiopathic Pulmonary Fibrosis (IPF). Fibrosis is driven by Inappropriate myofibroblast differentiation and persistence. Understanding this process, is vital for developing an effective… read more here.
Keywords: akt; atm kinase; activation; angii ... See more keywords
Cancer and Radiosensitivity Syndromes: Is Impaired Nuclear ATM Kinase Activity the Primum Movens?
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DOI: 10.3390/cancers14246141
Abstract: Simple Summary A review of the molecular and cellular features of the major cancer syndromes associated with radiosensitivity revealed the importance of the ATM protein, either as an impaired kinase in the nucleus or as… read more here.
Keywords: cancer radiosensitivity; atm kinase; cancer syndromes; radiosensitivity ... See more keywords
A Triphenylphosphonium-Functionalized Delivery System for an ATM Kinase Inhibitor That Ameliorates Doxorubicin Resistance in Breast Carcinoma Mammospheres
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DOI: 10.3390/cancers15051474
Abstract: Simple Summary Doxorubicin (DOX) is widely used in the treatment of breast cancer. However, resistance limits its effectiveness. In particular, breast cancer stem cells (BCSCs) are associated with DOX resistance. We have previously demonstrated the… read more here.
Keywords: system; atm kinase; breast; breast cancer ... See more keywords
ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23010523
Abstract: Ataxia–telangiectasia mutated (ATM) functions as a key initiator and coordinator of DNA damage and cellular stress responses. ATM signaling pathways contain many downstream targets that regulate multiple important cellular processes, including DNA damage repair, apoptosis,… read more here.
Keywords: kinase relevance; atm kinase; dna damage; atm functions ... See more keywords
Structure of the human ATM kinase and mechanism of Nbs1 binding
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.74218
Abstract: DNA double-strand breaks (DSBs) can lead to mutations, chromosomal rearrangements, genome instability, and cancer. Central to the sensing of DSBs is the ATM (Ataxia-telangiectasia mutated) kinase, which belongs to the phosphatidylinositol 3-kinase-related protein kinase (PIKK)… read more here.
Keywords: kinase; atm kinase; human atm; atm ... See more keywords