Petri nets and ODEs as complementary methods for comprehensive analysis on an example of the ATM–p53–NF- $$\kappa$$ κ B signaling pathways
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DOI: 10.1038/s41598-022-04849-0
Abstract: Intracellular processes are cascades of biochemical reactions, triggered in response to various types of stimuli. Mathematical models describing their dynamics have become increasingly popular in recent years, as tools supporting experimental work in analysis of… read more here.
Keywords: analysis; p53 kappa; petri nets; atm p53 ... See more keywords
ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells
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DOI: 10.1371/journal.pone.0237669
Abstract: Pancreatic beta cell death is a hallmark of type 1 and 2 diabetes (T1D/T2D), but the underlying molecular mechanisms are incompletely understood. Key proteins of the DNA damage response (DDR), including tumor protein P53 (P53,… read more here.
Keywords: cell survival; atm p53; beta cell; p53 ... See more keywords
Plumbagin Exhibits Genotoxicity and Induces G2/M Cell Cycle Arrest via ROS-Mediated Oxidative Stress and Activation of ATM-p53 Signaling Pathway in Hepatocellular Cells
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DOI: 10.3390/ijms24076279
Abstract: Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone, PLB), a naturally occurring naphthoquinone mainly isolated from the plant Plumbago zeylanica L., has been proven to possess anticancer activities towards multiple types of cancer. Although there has been an increasing amount of… read more here.
Keywords: cycle arrest; cycle; cell cycle; atm p53 ... See more keywords