Cellular cytokine receptor signaling and ATM pathway intersections affect hepatic DNA repair.
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DOI: 10.1016/j.cyto.2019.154946
Abstract: Pathways involving ataxia telangiectasia mutated (ATM) gene and its downstream partners and effectors are critical for the DNA damage response. Cell survival, proliferation and tissue homeostasis are dependent upon preservation of DNA integrity but additional… read more here.
Keywords: dna repair; dna; growth factors; atm pathway ... See more keywords
N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway
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DOI: 10.1186/s12943-019-0941-2
Abstract: BackgroundMYCN amplification or N-Myc overexpression is found in approximately 40% NEPC and up to 20% CRPC patients. N-Myc has been demonstrated to drive disease progression and hormonal therapeutic resistance of NEPC/CRPC. Here, we aim to… read more here.
Keywords: therapeutic resistance; resistance; atm pathway; 421 atm ... See more keywords