ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis
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DOI: 10.1038/s41467-020-14654-w
Abstract: Meiotic recombination is initiated by SPO11-induced double-strand breaks (DSBs). In most mammals, the methyltransferase PRDM9 guides SPO11 targeting, and the ATM kinase controls meiotic DSB numbers. Following MRE11 nuclease removal of SPO11, the DSB is… read more here.
Keywords: prdm9 regulate; spo11 bound; recombination; atm prdm9 ... See more keywords