ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance
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DOI: 10.1158/0008-5472.can-22-0435
Abstract: ATM signaling supports the differentiation of myoCAFs to suppress T-cell infiltration and antitumor immunity, supporting the potential clinical use of ATM inhibitors in combination with checkpoint inhibition in myoCAF-rich, immune-cold tumors. read more here.
Keywords: differentiation myofibroblastic; regulates differentiation; atm regulates; atm ... See more keywords
The DNA repair kinase ATM regulates CD13 expression and cell migration
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DOI: 10.3389/fcell.2024.1359105
Abstract: Classically, ATM is known for its role in sensing double-strand DNA breaks, and subsequently signaling for their repair. Non-canonical roles of ATM include transcriptional silencing, ferroptosis, autophagy and angiogenesis. Angiogenesis mediated by ATM signaling has… read more here.
Keywords: migration; regulates cd13; cell migration; cd13 ... See more keywords