Atoh1 Controls Primary Cilia Formation to Allow for SHH-Triggered Granule Neuron Progenitor Proliferation.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.12.017
Abstract: During cerebellar development, granule neuron progenitors (GNPs) proliferate by transducing Sonic Hedgehog (SHH) signaling via the primary cilium. Precise regulation of ciliogenesis, thus, ensures proper GNP pool expansion. Here, we report that Atoh1, a transcription… read more here.
Keywords: atoh1; granule neuron; formation; gnps ... See more keywords
Phospho-regulation of ATOH1 Is Required for Plasticity of Secretory Progenitors and Tissue Regeneration
Sign Up to like & getrecommendations! Published in 2018 at "Cell Stem Cell"
DOI: 10.1016/j.stem.2018.07.002
Abstract: Summary The intestinal epithelium is largely maintained by self-renewing stem cells but with apparently committed progenitors also contributing, particularly following tissue damage. However, the mechanism of, and requirement for, progenitor plasticity in mediating pathological response… read more here.
Keywords: secretory progenitors; regeneration; atoh1 required; atoh1 ... See more keywords
Three distinct Atoh1 enhancers cooperate for sound receptor hair cell development
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2119850119
Abstract: Significance The expression of Atoh1, a gene essential for cochlear hair cell (HC) development, is tightly regulated. A previously identified Atoh1 enhancer is considered vital for regulating Atoh1 expression, but direct evidence is lacking. It… read more here.
Keywords: atoh1 enhancers; atoh1; hair cell; expression ... See more keywords
Absence of Atoh1 induced partially different cell fates of cochlear and vestibular sensory epithelial cells in mice
Sign Up to like & getrecommendations! Published in 2018 at "Acta Oto-Laryngologica"
DOI: 10.1080/00016489.2018.1497855
Abstract: Abstract Background： Atoh1, also named Math1, is essential for the development of inner ear hair cells. Many studies have confirmed that the absence of Atoh1 resulted in a total loss of inner ear hair cells,… read more here.
Keywords: cochlea vestibule; hair cells; epithelial cells; atoh1 ... See more keywords
The Repression of Atoh1 by Neurogenin1 during Inner Ear Development
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00321
Abstract: Atonal homolog 1 (Atoh1) and Neurogenin1 (Neurog1) are basic Helix-Loop-Helix (bHLH) transcription factors crucial for the generation of hair cells (HCs) and neurons in the inner ear. Both genes are induced early in development, but… read more here.
Keywords: inner ear; repression atoh1; atoh1; atoh1 neurogenin1 ... See more keywords