Atopic Multimorbidity in Adults With a Focus on Sensitization Patterns and T Cell Activation
Sign Up to like & getrecommendations! Published in 2025 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.70129
Abstract: ABSTRACT Background Atopic diseases—including atopic dermatitis (AD), asthma (AA), and allergic rhinitis (AR)—are driven by Th2 inflammation and often occur together (atopic multimorbidity), along with non‐atopic comorbidities. Chronic spontaneous urticaria (CSU) is an autoimmune mast… read more here.
Keywords: cell activation; atopic; atopic multimorbidity; atopic diseases ... See more keywords
Dupilumab: a delayed response in asthmatic and atopic patients treated for chronic rhinosinusitis with nasal polyps
Sign Up to like & getrecommendations! Published in 2024 at "European Archives of Oto-Rhino-Laryngology"
DOI: 10.1007/s00405-024-08738-2
Abstract: Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a common disease, which was previously approached with sinus surgery or systemic corticosteroids. The advent of biological therapies radically changed the approach to this disease. On the other… read more here.
Keywords: chronic rhinosinusitis; response; atopic patients; rhinosinusitis nasal ... See more keywords
A Multidisciplinary Approach Is Beneficial in Atopic Dermatitis
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DOI: 10.1007/s13555-024-01185-1
Abstract: Atopic dermatitis (AD) is a highly heterogeneous chronic inflammatory skin disorder that is frequently associated with a plethora of comorbidities. AD is, therefore, considered a systemic disease impacted by a considerable burden and leading to… read more here.
Keywords: approach beneficial; multidisciplinary approach; atopic; atopic dermatitis ... See more keywords
Systemic Therapy of Atopic Dermatitis: When, How, for How Long?
Sign Up to like & getrecommendations! Published in 2017 at "Current Dermatology Reports"
DOI: 10.1007/s13671-017-0176-7
Abstract: Purpose of ReviewThe increasingly recognized nature of atopic dermatitis/AD as a cytokine-driven, systemic disease has led to rapid development of target-specific therapies. We review advances in systemic treatments for AD, including indications for use, as… read more here.
Keywords: atopic dermatitis; atopic; therapy atopic; systemic therapy ... See more keywords
The Microbiome and Atopic Dermatitis: A Review
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Clinical Dermatology"
DOI: 10.1007/s40257-019-00467-1
Abstract: The microbiome is defined as the sum of microbes, their genomes, and interactions in a given ecological niche. Atopic dermatitis is a multifactorial chronic inflammatory skin disease leading to dryness and itchiness of the skin.… read more here.
Keywords: dermatology; atopic dermatitis; microbiome atopic; dermatitis review ... See more keywords
Appraisal of Proactive Topical Therapy in Atopic Dermatitis: Pros and Cons
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Clinical Dermatology"
DOI: 10.1007/s40257-021-00629-0
Abstract: Atopic dermatitis is a common inflammatory skin disease that can affect both children and adults. It is a chronic disease with recurrent, highly pruritic eczematous lesions. Topical treatment with anti-inflammatory agents is the mainstay of… read more here.
Keywords: treatment; disease; atopic dermatitis; therapy ... See more keywords
Innovation in Atopic Dermatitis: From Pathogenesis to Treatment.
Sign Up to like & getrecommendations! Published in 2020 at "Actas dermo-sifiliograficas"
DOI: 10.1016/j.ad.2019.11.002
Abstract: Atopic dermatitis is the most common inflammatory skin disease and up to 20% of cases can be classified as moderate to severe. Our understanding of the pathogenesis of this disease has improved in recent years.… read more here.
Keywords: innovation atopic; treatment; pathogenesis; atopic dermatitis ... See more keywords
IL-4Rα Inhibitor for Atopic Disease
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.06.046
Abstract: Dupilumab is a fully human IgG4 monoclonal antibody directed against the IL-4Rα subunit of IL-4 and IL-13 receptors. It blocks the signaling pathways of IL-4 and IL-13, key cytokines that drive type 2 inflammatory response.… read more here.
Keywords: atopic disease; atopic; inhibitor atopic;
A defective release of host defense peptides is present in canine atopic skin.
Sign Up to like & getrecommendations! Published in 2019 at "Comparative immunology, microbiology and infectious diseases"
DOI: 10.1016/j.cimid.2019.04.008
Abstract: The use of dogs as animal model for human atopic dermatitis (AD) is well known. Striking similarities in the pathogenesis of AD have been demonstrated. Similar alteration of host defense peptides (HDP) have been identified… read more here.
Keywords: host defense; defense peptides; skin; atopic ... See more keywords
Atopic dermatitis: Part I.
Sign Up to like & getrecommendations! Published in 2017 at "Clinics in dermatology"
DOI: 10.1016/j.clindermatol.2017.03.003
Abstract: Atopic dermatitis is a chronic inflammatory skin disorder. The first recorded cases date back to the Roman era and have been a source of controversy and discomfort ever since.1 The Global Burden of Disease study… read more here.
Keywords: atopic dermatitis; atopic; dermatitis part;
Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.09.033
Abstract: Phosphatidylinositide 3-kinases (PI3Ks) are widely expressed enzymes involved in membrane signalization pathways. Attempts to administer inhibitors with broad activity against different isoforms have failed due to toxicity. Conversely the PI3Kδ isoform is much more selectively… read more here.
Keywords: anti pi3k; compound; preclinical models; atopic ... See more keywords