Effect of Roxadustat on the Pharmacokinetics of Simvastatin, Rosuvastatin, and Atorvastatin in Healthy Subjects: Results From 3 Phase 1, Open‐Label, 1‐Sequence, Crossover Studies
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DOI: 10.1002/cpdd.1076
Abstract: Roxadustat inhibits breast cancer resistance protein and organic anion transporting polypeptide 1B1, which can affect coadministered statin concentrations. Three open‐label, 1‐sequence crossover phase 1 studies in healthy subjects were conducted to assess effects from steady‐state… read more here.
Keywords: roxadustat; label sequence; sequence crossover; atorvastatin ... See more keywords
Assessment of Pharmacokinetic Drug Interaction of Asciminib with Atorvastatin in Healthy Participants.
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DOI: 10.1002/cpdd.1611
Abstract: Asciminib is the first BCR::ABL1 inhibitor that Specifically Targets the ABL Myristoyl Pocket (STAMP) in patients with chronic myeloid leukemia. This phase 1, two-treatment-period, drug-drug interaction study evaluated the effect of steady-state asciminib on the… read more here.
Keywords: healthy participants; asciminib atorvastatin; drug interaction; drug ... See more keywords
Pharmacokinetic and Safety Profiles of a Fixed‐Dose Combination of Amlodipine, Valsartan, and Atorvastatin: A 3‐Period Replicate Crossover Study
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.727
Abstract: The objective of study was to compare the pharmacokinetic and safety profiles of a fixed‐dose combination (FDC) formulation of 5/160/20 mg amlodipine/valsartan/atorvastatin with those of separate formulations of a 5/160‐mg amlodipine/valsartan tablet and a 20‐mg… read more here.
Keywords: valsartan atorvastatin; amlodipine valsartan; period replicate; atorvastatin ... See more keywords
Pharmacokinetics of Atorvastatin and Metformin after Coadministration with Islatravir in Healthy Adults
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Pharmacology"
DOI: 10.1002/jcph.6169
Abstract: Islatravir, a deoxyadenosine analog that inhibits HIV‐1 replication by multiple mechanisms of action, including reverse transcriptase translocation inhibition, is being developed for use in HIV‐1 treatment. People living with HIV often have comorbidities, such as… read more here.
Keywords: islatravir; coadministration; atorvastatin; healthy adults ... See more keywords
Discontinuation of atorvastatin use in hospital is associated with increased risk of mortality in COVID‐19 patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hospital Medicine"
DOI: 10.1002/jhm.12789
Abstract: Background Statins are a commonly used class of drugs, and reports have suggested that their use may affect COVID-19 disease severity and mortality risk. Objective The purpose of this analysis was to determine the effect… read more here.
Keywords: atorvastatin use; therapy; atorvastatin; use ... See more keywords
Survival of the hospitalized patients with COVID‐19 receiving atorvastatin: A randomized clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27710
Abstract: As statins decrease the progression of sepsis and its related mortality, this study aimed to evaluate the effect of atorvastatin on survival and symptom improvement in hospitalized patients with COVID‐19. This randomized controlled trial was… read more here.
Keywords: hospitalized patients; survival; group; atorvastatin ... See more keywords
Rapid ultrasound-assisted microextraction of atorvastatin in the sample of blood plasma by Ni metal organic modified with alumina nanoparticles.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000660
Abstract: In the present work, Ni-1,4-benzenedioxyacetic acid was synthesized as a rod-like metal organic material and then modified with alumina nanoparticles to synthesize Ni-MOM-Al2 O3 nanoparticles. The material was found as an efficient sorbent for the… read more here.
Keywords: extraction; plasma; atorvastatin; metal organic ... See more keywords
Atorvastatin Relieves Cognitive Disorder After Sepsis Through Reverting Inflammatory Cytokines, Oxidative Stress, and Neuronal Apoptosis in Hippocampus
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DOI: 10.1007/s10571-019-00750-z
Abstract: This present research work reports the possible effects and the underlying mechanism of atorvastatin on survival rate and cognitive disorders after sepsis. Sepsis is a life-threatening dysfunction that arises when the body’s response to infection causes injury to… read more here.
Keywords: hippocampus; cytokines oxidative; atorvastatin; stress neuronal ... See more keywords
Atorvastatin Protects Against the Macrophage/Microglia-Related Neuroinflammation via Inhibiting Lipocalin-2 in Mouse Experimental Intracerebral Hemorrhage Model
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DOI: 10.1007/s10571-025-01566-w
Abstract: There are few effective pharmacological interventions for intracerebral hemorrhage (ICH). Atorvastatin (Ato) has been shown to exert a substantial protective effect on ischemic stroke and is effective in alleviating neuroinflammation. Lipocalin-2 (LCN2), an important inflammation-regulating… read more here.
Keywords: neuroinflammation; lcn2; macrophage microglia; intracerebral hemorrhage ... See more keywords
Synergistic Cardioprotective Effects of Combined Chromium Picolinate and Atorvastatin Treatment in Triton X-100-Induced Hyperlipidemia in Rats: Impact on Some Biochemical Markers
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DOI: 10.1007/s12011-017-1010-6
Abstract: Hyperlipidemia is one of the major risk factors for atherosclerosis and ischemic heart disease. Chromium (Cr) mineral is playing a crucial role in glucose and lipid homeostasis. The aim of this study was to evaluate… read more here.
Keywords: hyperlipidemia; treatment; group; atorvastatin ... See more keywords
Pharmacokinetic Comparison of a Fixed-Dose Combination of Candesartan Cilexetil/Amlodipine/Atorvastatin Versus Co-administration of Individual Formulations in Healthy Participants
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DOI: 10.1007/s12325-024-02869-y
Abstract: Fixed-dose combinations (FDCs) of angiotensin II receptor blockers, calcium channel blockers, and statins are conventional therapeutic interventions prescribed for cardiovascular diseases. This study aimed at drawing a comparison between the pharmacokinetics and safety of an… read more here.
Keywords: candesartan cilexetil; cilexetil amlodipine; individual formulations; amlodipine atorvastatin ... See more keywords