Effect of Roxadustat on the Pharmacokinetics of Simvastatin, Rosuvastatin, and Atorvastatin in Healthy Subjects: Results From 3 Phase 1, Open‐Label, 1‐Sequence, Crossover Studies
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DOI: 10.1002/cpdd.1076
Abstract: Roxadustat inhibits breast cancer resistance protein and organic anion transporting polypeptide 1B1, which can affect coadministered statin concentrations. Three open‐label, 1‐sequence crossover phase 1 studies in healthy subjects were conducted to assess effects from steady‐state… read more here.
Keywords: roxadustat; label sequence; sequence crossover; atorvastatin ... See more keywords
Pharmacokinetic and Safety Profiles of a Fixed‐Dose Combination of Amlodipine, Valsartan, and Atorvastatin: A 3‐Period Replicate Crossover Study
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.727
Abstract: The objective of study was to compare the pharmacokinetic and safety profiles of a fixed‐dose combination (FDC) formulation of 5/160/20 mg amlodipine/valsartan/atorvastatin with those of separate formulations of a 5/160‐mg amlodipine/valsartan tablet and a 20‐mg… read more here.
Keywords: valsartan atorvastatin; amlodipine valsartan; period replicate; atorvastatin ... See more keywords
Discontinuation of atorvastatin use in hospital is associated with increased risk of mortality in COVID‐19 patients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hospital Medicine"
DOI: 10.1002/jhm.12789
Abstract: Background Statins are a commonly used class of drugs, and reports have suggested that their use may affect COVID-19 disease severity and mortality risk. Objective The purpose of this analysis was to determine the effect… read more here.
Keywords: atorvastatin use; therapy; atorvastatin; use ... See more keywords
Survival of the hospitalized patients with COVID‐19 receiving atorvastatin: A randomized clinical trial
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.27710
Abstract: As statins decrease the progression of sepsis and its related mortality, this study aimed to evaluate the effect of atorvastatin on survival and symptom improvement in hospitalized patients with COVID‐19. This randomized controlled trial was… read more here.
Keywords: hospitalized patients; survival; group; atorvastatin ... See more keywords
Rapid ultrasound-assisted microextraction of atorvastatin in the sample of blood plasma by Ni metal organic modified with alumina nanoparticles.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of separation science"
DOI: 10.1002/jssc.202000660
Abstract: In the present work, Ni-1,4-benzenedioxyacetic acid was synthesized as a rod-like metal organic material and then modified with alumina nanoparticles to synthesize Ni-MOM-Al2 O3 nanoparticles. The material was found as an efficient sorbent for the… read more here.
Keywords: extraction; plasma; atorvastatin; metal organic ... See more keywords
Atorvastatin Relieves Cognitive Disorder After Sepsis Through Reverting Inflammatory Cytokines, Oxidative Stress, and Neuronal Apoptosis in Hippocampus
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00750-z
Abstract: This present research work reports the possible effects and the underlying mechanism of atorvastatin on survival rate and cognitive disorders after sepsis. Sepsis is a life-threatening dysfunction that arises when the body’s response to infection causes injury to… read more here.
Keywords: hippocampus; cytokines oxidative; atorvastatin; stress neuronal ... See more keywords
Synergistic Cardioprotective Effects of Combined Chromium Picolinate and Atorvastatin Treatment in Triton X-100-Induced Hyperlipidemia in Rats: Impact on Some Biochemical Markers
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DOI: 10.1007/s12011-017-1010-6
Abstract: Hyperlipidemia is one of the major risk factors for atherosclerosis and ischemic heart disease. Chromium (Cr) mineral is playing a crucial role in glucose and lipid homeostasis. The aim of this study was to evaluate… read more here.
Keywords: hyperlipidemia; treatment; group; atorvastatin ... See more keywords
Evaluation of Pharmacokinetic Drug Interactions of the Direct-Acting Antiviral Agents Elbasvir and Grazoprevir with Pitavastatin, Rosuvastatin, Pravastatin, and Atorvastatin in Healthy Adults
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Drug Investigation"
DOI: 10.1007/s40261-020-00974-8
Abstract: Many people infected with hepatitis C virus have comorbidities, including hypercholesterolemia, that are treated with statins. In this study, we evaluated the drug–drug interaction potential of the hepatitis C virus inhibitors elbasvir (EBR) and grazoprevir… read more here.
Keywords: ebr gzr; gzr; atorvastatin; drug ... See more keywords
Atorvastatin prevents Angiotensin II induced myocardial hypertrophy in vitro via CCAAT/enhancer-binding protein β.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.057
Abstract: Previous evidences suggested that atorvastatin not only reduced blood lipids but also reduced myocardial hypertrophy and remodeling. And it was reported that C/EBPβ (CCAAT/enhancer-binding protein β) played a pivotal role both in the physiologic and… read more here.
Keywords: ccaat enhancer; atorvastatin; hypertrophy; enhancer binding ... See more keywords
Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXRα through structure-based virtual screening.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.01.007
Abstract: Retinoid X receptor alpha (RXRα), a central member of the nuclear receptor superfamily and a key regulator of many signal transduction pathways, has been an attractive drug target. We previously discovered that an N-terminally truncated… read more here.
Keywords: tetramer stabilizer; screening; atorvastatin; nuclear receptor ... See more keywords
Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2019.01.018
Abstract: Clinical and pre-clinical evidences indicate an association between inflammation and depression since increased levels of pro-inflammatory cytokines are associated with depression-related symptoms. Atorvastatin is a cholesterol-lowering statin that possesses pleiotropic effects including neuroprotective and antidepressant… read more here.
Keywords: lps induced; treatment; atorvastatin; like behaviour ... See more keywords