Surface stabilized atorvastatin nanocrystals with improved bioavailability, safety and antihyperlipidemic potential
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DOI: 10.1038/s41598-019-52645-0
Abstract: Atorvastatin, a favored option for hyperlipidemia exhibits the problem of poor gastric solubility and low absolute bioavailability (12%) along with higher pre-systemic clearance (>80%). Therefore, to circumvent these limitations, atorvastatin nanocrystals were prepared using poloxamer-188… read more here.
Keywords: atorvastatin nanocrystals; surface stabilized; bioavailability; safety ... See more keywords