Nanoemulsion of atovaquone as a promising approach for treatment of acute and chronic toxoplasmosis
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.02.018
Abstract: &NA; Treatment of toxoplasmosis is necessary in congenital form and immunocompromised patients. Atovaquone is a powerful suppressor of protozoan parasites with a broadâspectrum activity, but an extremely low water solubility and bioavailability. In this study,… read more here.
Keywords: nanoemulsion atovaquone; atovaquone; treatment; toxoplasmosis ... See more keywords
Use of tafenoquine to treat a patient with relapsing babesiosis with clinical and molecular evidence of resistance to azithromycin and atovaquone
Sign Up to like & getrecommendations! Published in 2022 at "IDCases"
DOI: 10.1016/j.idcr.2022.e01460
Abstract: Tafenoquine is a highly effective treatment for Babesia microti infections in animal models. An immunocompromised patient infected by a strain of B. microti that was at least partially resistant to both azithromycin and atovaquone was… read more here.
Keywords: use tafenoquine; treat patient; azithromycin atovaquone; tafenoquine treat ... See more keywords
Babesia microti Variant With Multiple Resistance Mutations Detected in an Immunocompromised Patient Receiving Atovaquone Prophylaxis
Sign Up to like & getrecommendations! Published in 2023 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofad097
Abstract: Abstract We report Babesia microti genomic sequences with multiple mutations in the atovaquone-target region of cytochrome b, including a newly identified Y272S mutation, plus 1 mutation of undetermined significance in the azithromycin-associated ribosomal protein L4.… read more here.
Keywords: microti variant; variant multiple; atovaquone; immunocompromised patient ... See more keywords
Abstract LB-125: Atovaquone suppresses triple negative breast tumor growth by inhibiting myeloid derived suppressor cells
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1158/1538-7445.am2018-lb-125
Abstract: Triple negative breast cancer (TNBC) is considered to be the most aggressive and malignant neoplasm and is highly metastatic in nature. Metastatic TNBC is difficult to treat thus leading to extremely poor survival. The major… read more here.
Keywords: cancer; atovaquone; breast; tumor growth ... See more keywords
Abstract 6395: Atovaquone promotes release of damage-associated molecular patterns from epithelial ovarian cancer cells
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6395
Abstract: Epithelial ovarian cancer (EOC) is the deadliest gynecologic cancer in the United States. Most patients are diagnosed with EOC at advanced stages and have limited treatment options. Developing new therapies that are effective against localized… read more here.
Keywords: cell; epithelial ovarian; damage; atovaquone ... See more keywords
Atovaquone attenuates experimental colitis by reducing neutrophil infiltration of colonic mucosa
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1011115
Abstract: Ulcerative colitis (UC) is a chronic relapsing disease featuring aberrant accumulation of neutrophils in colonic mucosa and the luminal space. Although significant advances in UC therapy have been made with the development of novel biologics… read more here.
Keywords: colonic mucosa; reducing neutrophil; colitis reducing; atovaquone ... See more keywords
Atovaquone: An Inhibitor of Oxidative Phosphorylation as Studied in Gynecologic Cancers
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14092297
Abstract: Simple Summary The Warburg effect in cancer cells (high glucose update and lactate release) is an adaptation that is considered a hallmark of most neoplasms. Blocking oxidative phosphorylation is one way to combat carcinogenesis. Atovaquone… read more here.
Keywords: gynecologic cancers; oxidative phosphorylation; atovaquone; oxygen ... See more keywords
Repurposing Atovaquone as a Therapeutic against Acute Myeloid Leukemia (AML): Combination with Conventional Chemotherapy Is Feasible and Well Tolerated
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15041344
Abstract: Simple Summary Novel well-tolerated agents are urgently needed to improve outcomes for children with acute myeloid leukemia. Atovaquone is an anti-infective agent which can be used to prevent and treat a type of pneumonia that… read more here.
Keywords: myeloid leukemia; atovaquone; aml; leukemia ... See more keywords