P2X2 receptor subunit interfaces are missense variant hotspots, where mutations tend to increase apparent ATP affinity
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DOI: 10.1101/2021.03.26.436616
Abstract: Background and Purpose P2X receptors (P2XRs) are trimeric ligand-gated ion channels (LGICs) that open a cation-selective pore in response to ATP binding to their large extracellular domain (ECD). The seven known P2XR subtypes can assemble… read more here.
Keywords: subunit interfaces; p2x2 receptor; apparent atp; atp affinity ... See more keywords