Antisense Oligonucleotides Selectively Enter Human-derived Antibiotic-Resistant Bacteria through bacterial-specific ATP-binding Cassette Sugar Transporter.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202300477
Abstract: Current vehicles used to deliver antisense oligonucleotides (ASOs) cannot distinguish between bacterial and mammalian cells, greatly hindering the preclinical or clinical treatment of bacterial infections, especially those caused by antibiotic-resistant bacteria. Herein, we leverage the… read more here.
Keywords: atp binding; antisense oligonucleotides; binding cassette; antibiotic resistant ... See more keywords
The human ATP‐binding cassette (ABC) transporter superfamily
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24418
Abstract: The ATP‐binding cassette (ABC) transporter superfamily comprises membrane proteins that efflux various substrates across extra‐ and intracellular membranes. Mutations in ABC genes cause 21 human disorders or phenotypes with Mendelian inheritance, including cystic fibrosis, adrenoleukodystrophy,… read more here.
Keywords: atp binding; binding cassette; abc transporter; abc ... See more keywords
Allosteric Small-Molecule Serine/Threonine Kinase Inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8719-7_11
Abstract: Deregulation of protein kinase activity has been linked to many diseases ranging from cancer to AIDS and neurodegenerative diseases. Not surprisingly, drugging the human kinome - the complete set of kinases encoded by the human… read more here.
Keywords: kinase inhibitors; serine threonine; kinase; atp binding ... See more keywords
Nanomolar ATP binding to single myosin cross-bridges in rigor: a molecular approach to studying myosin ATP kinetics using single human cardiomyocytes
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical Reviews"
DOI: 10.1007/s12551-020-00716-2
Abstract: Our knowledge in the field of cardiac muscle and associated cardiomyopathies has been evolving incrementally over the past 60 years and all was possible due to the parallel progress in techniques and methods allowing to… read more here.
Keywords: single molecule; myosin; nanomolar atp; atp binding ... See more keywords
Cloning and tissue distribution of the ATP-binding cassette subfamily G member 2 gene in the marine pufferfish Takifugu rubripes
Sign Up to like & getrecommendations! Published in 2020 at "Fisheries Science"
DOI: 10.1007/s12562-020-01451-z
Abstract: In this study, we cloned the ATP-binding cassette (ABC) subfamily G member 2 gene (Abcg2 gene; breast cancer resistance protein) from the liver of the marine pufferfish Takifugu rubripes, and examined its tissue distribution and… read more here.
Keywords: member gene; subfamily member; atp binding; marine pufferfish ... See more keywords
Ganciclovir and maribavir susceptibility phenotypes of cytomegalovirus UL97 ATP binding region mutations detected by expanded genotypic testing.
Sign Up to like & getrecommendations! Published in 2021 at "Antiviral research"
DOI: 10.1016/j.antiviral.2021.105139
Abstract: Because ganciclovir resistance mutations in the cytomegalovirus UL97 gene most commonly occur at codons 460, 520 and 590-607, diagnostic genotyping for drug resistance has often omitted the analysis of codons below 440. However, the UL97… read more here.
Keywords: binding region; maribavir; ganciclovir maribavir; atp binding ... See more keywords
Maize MS2 encodes an ATP-binding cassette transporter that is essential for anther development
Sign Up to like & getrecommendations! Published in 2021 at "Crop Journal"
DOI: 10.1016/j.cj.2021.04.001
Abstract: Abstract The anther cuticle and pollen exine play a critical role in male gametophyte development. The sporopollenin precursors and cuticular lipid monomers are transported to the surface of the microspores and the epidermis by lipid… read more here.
Keywords: transporter; development; binding cassette; anther development ... See more keywords
Novel Drosophila model for psychiatric disorders including autism spectrum disorder by targeting of ATP-binding cassette protein A
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2017.10.027
Abstract: ABSTRACT Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interactions, as well as restricted, stereotyped patterns of behavior and interests. In addition, alterations in circadian sleep‐wake rhythm are common… read more here.
Keywords: drosophila; dabca; spectrum disorder; atp binding ... See more keywords
Identification and mechanistic analysis of an inhibitor of the CorC Mg2+ transporter
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DOI: 10.1016/j.isci.2021.102370
Abstract: Summary The CorC/CNNM family of Na+-dependent Mg2+ transporters is ubiquitously conserved from bacteria to humans. CorC, the bacterial CorC/CNNM family of proteins, is involved in resistance to antibiotic exposure and in the survival of pathogenic… read more here.
Keywords: corc cnnm; binding site; atp binding; cnnm family ... See more keywords
Inhibition of microRNA-17-5p reduces the inflammation and lipid accumulation, and up-regulates ATP-binding cassette transporterA1 in atherosclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2018.11.012
Abstract: Atherosclerosis (AS) is a chronic inflammatory disease of the arterial wall. Macrophages are considered to be closely associated with the development and progression of AS. However, the precise mechanism of miR-17-5p in the macrophages under… read more here.
Keywords: inflammation lipid; lipid accumulation; mir; atp binding ... See more keywords
Role of ATP-binding cassette transporter A1 in suppressing lipid accumulation by glucagon-like peptide-1 agonist in hepatocytes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.12.015
Abstract: Objective Adenosine triphosphate (ATP)-binding cassette transporter A1 (ABCA1) influences hepatic cholesterol transportation. Accumulation of hepatic cholesterol leads to fatty liver disease, which is improved by glucagon-like peptide 1 (GLP-1) in diabetes. Therefore, we analyzed the… read more here.
Keywords: accumulation; lipid accumulation; hepatic abca1; atp binding ... See more keywords