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1
Published in 2019 at "Protein Science"
DOI: 10.1002/pro.3708
Abstract: ATP‐citrate lyase (ACLY) catalyzes production of acetyl‐CoA and oxaloacetate from CoA and citrate using ATP. In humans, this cytoplasmic enzyme connects energy metabolism from carbohydrates to the production of lipids. In certain bacteria, ACLY is…
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Keywords:
site residues;
atp citrate;
active site;
portion ... See more keywords
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1
Published in 2019 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-019-01863-0
Abstract: Chronic or non-communicable diseases are the leading cause of death worldwide; they usually result in long-term illnesses and demand long-term care. Despite advances in molecular therapeutics, specific biomarkers and targets for the treatment of these…
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Keywords:
citrate lyase;
chronic diseases;
atp citrate;
role ... See more keywords
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1
Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.04.015
Abstract: Branched-chain amino acids (BCAA) are strongly associated with dysregulated glucose and lipid metabolism, but the underlying mechanisms are poorly understood. We report that inhibition of the kinase (BDK) or overexpression of the phosphatase (PPM1K) that…
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Keywords:
citrate lyase;
atp citrate;
metabolism;
lipid metabolism ... See more keywords
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1
Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.09.001
Abstract: ATP citrate lyase (ACLY) is a cytosolic homotetrameric enzyme that catalyzes the conversion of citrate and coenzyme A (CoA) to acetyl-CoA and oxaloacetate, with the simultaneous hydrolysis of ATP to ADP and phosphate. Interestingly, ACLY…
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Keywords:
atp citrate;
citrate;
acly inhibitors;
metabolism ... See more keywords
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0
Published in 2020 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2020.112614
Abstract: Six undescribed clerodane diterpenoids, dodovisins A-F, together with nine known ones, were isolated from the aerial parts of Dodonaea viscosa (L.) Jacq. Their structures were elucidated by extensive spectroscopic techniques, X-ray crystallographic analysis, and ECD…
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Keywords:
citrate lyase;
atp citrate;
clerodane;
clerodane diterpenoids ... See more keywords
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1
Published in 2020 at "Redox Biology"
DOI: 10.1016/j.redox.2020.101446
Abstract: Both the accumulation of Amyloid-β (Aβ) in plaques and phosphorylation of Tau protein (p-Tau) in neurofibrillary tangles have been identified as two major symptomatic features of Alzheimer's disease (AD). Despite of critical role of Aβ…
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Keywords:
citrate lyase;
atp citrate;
tau;
phosphorylation ... See more keywords
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Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(17)35044-1
Abstract: Background: Bempedoic acid is a novel oral agent that reduces hepatic cholesterol synthesis by inhibiting ATP-citrate lyase (ACL) leading to upregulation of the LDL receptor and a reduction in plasma low-density lipoprotein cholesterol (LDL-C). Although…
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Keywords:
citrate lyase;
atp citrate;
target validation;
genetic target ... See more keywords
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0
Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-20141-z
Abstract: Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation…
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Keywords:
citrate lyase;
deficiency;
atp citrate;
atherosclerotic plaques ... See more keywords
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1
Published in 2020 at "RSC Advances"
DOI: 10.1039/c9ra09542j
Abstract: Fourteen previously undescribed naturally occurring C-23 carboxylated triterpenoids, stewartiacids A–N (1–14), were isolated and characterized from the twigs and leaves of the ornamental and medicinal plant Stewartia sinensis (Chinese Stewartia), a ‘vulnerable’ species endemic to…
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Keywords:
citrate lyase;
atp citrate;
inhibitory effects;
carboxylated triterpenoids ... See more keywords
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Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1773314
Abstract: Abstract ATP citrate lyase (ACLY) is an important enzyme that catalyzes the conversion of citrate to acetyl-CoA in normal cells, facilitating the de novo fatty acid synthesis. Lipids and fatty acids were found to be…
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Keywords:
citrate lyase;
atp citrate;
citrate;
pharmacophore based ... See more keywords
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1
Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2067478
Abstract: ABSTRACT Introduction ATP citrate lyase (ACLY) is a key enzyme in cellular metabolism, being the main source of acetyl-Coenzyme A, an important precursor for fatty acid, cholesterol, and isoprenoid biosynthesis, and it is also involved…
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Keywords:
citrate lyase;
lyase acly;
acly;
atp citrate ... See more keywords